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Mini Episode: Managing Crashing Hydroxychloroquine/Chloroquine OD
Manage episode 337597523 series 3382933
Content provided by Ryan Feldman and Ryan Feldman PharmD DABAT. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Ryan Feldman and Ryan Feldman PharmD DABAT or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Quick review
- Toxic dose
- Chloroquine >5g severe toxicity is expected (toxicity may develop below this)
- HCQ less well defind
- Clinical effects
- Seizures (sodium channel blockade)
- Arrhythmia (sodium channel blockade)
- Hypotension (Alpha blockade)
- Hypokalemia
- Management
- Activated Charcoal if awake and alert and no risk of emesis
- Early invasive supportive care based on the following retrospective case control series https://www.nejm.org/doi/full/10.1056/NEJM198801073180101
- High dose epinephrine (0.25 mcg/kg/min)
- Diazepam 1-2 mg/kg over 30 minutes followed by 1-2 mg/kg over 24 hours (seizure prevention)
- Evidence supports this may be cardio protective as well
- Early intubation
- Consultation with poison center recommended 1-800-222-1222
52 episodes
Share
Manage episode 337597523 series 3382933
Content provided by Ryan Feldman and Ryan Feldman PharmD DABAT. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Ryan Feldman and Ryan Feldman PharmD DABAT or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Quick review
- Toxic dose
- Chloroquine >5g severe toxicity is expected (toxicity may develop below this)
- HCQ less well defind
- Clinical effects
- Seizures (sodium channel blockade)
- Arrhythmia (sodium channel blockade)
- Hypotension (Alpha blockade)
- Hypokalemia
- Management
- Activated Charcoal if awake and alert and no risk of emesis
- Early invasive supportive care based on the following retrospective case control series https://www.nejm.org/doi/full/10.1056/NEJM198801073180101
- High dose epinephrine (0.25 mcg/kg/min)
- Diazepam 1-2 mg/kg over 30 minutes followed by 1-2 mg/kg over 24 hours (seizure prevention)
- Evidence supports this may be cardio protective as well
- Early intubation
- Consultation with poison center recommended 1-800-222-1222
52 episodes
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Similar to The Poison Lab
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
PT Inquest is an online journal club. Hosted by Jason Tuori, Megan Graham, and Chris Juneau, the show looks at an article every week and discusses how it applies to current physical therapy practice.
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
The Naked Scientists flagship science show brings you a lighthearted look at the latest scientific breakthroughs, interviews with the world's top scientists, answers to your science questions and science experiments to try at home.
…
continue reading
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…
continue reading
Deep in the back of your mind, you’ve always had the feeling that there’s something strange about reality. There is. Join Robert Lamb and Joe McCormick as they examine neurological quandaries, cosmic mysteries, evolutionary marvels and our transhuman future.
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
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continue reading
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Go offline with the Player FM app!
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