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43: LIVE from AOSSM: The Future of Orthobiologics is Now! (Dr. Scott Rodeo)
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Dr. Scott Rodeo is a professor of Orthopaedic Surgery Weill Cornell Medical School and an attending surgeon at the Hospital for Special Surgery. He is the head team physician for the NY Giants, Co-Chief Emeritus of the Sports Medicine & Shoulder Service and Vice Chair of Orthopaedic Research. Dr. Rodeo is also the Director of the Center for Regenerative Medicine and is a renowned expert in the field of orthobiologics - so we’re excited to hear more from him about this rapidly growing field.
In this episode, we discuss:
What are genetically modified bone marrow derived stem cells? What have studies shown as it pertains to augmenting cuff repair?
Why use fully differentiated endothelial cells rather than pluripotent stem cells derived from bone marrow? What is so special about this cell population?
What were the main findings of the study investigating the use of genetically modified Human Umbilical Vein Endothelial Cells (HUVEC) to augment repair of full thickness rotator cuff tears?
Method of delivering stems cells to the area of pathology (and keeping them there!) is important. What are some tips/ tricks to ensure the cells stay put at the cuff repair?
Stem cells were injected around the tendon but also into the muscle itself - why?
Is there any change in the rehab protocol after stem cell use? Any period of activity shut down when used in the non-op setting?
What other orthopaedic conditions would benefit from application of this genetically modified cell-based therapy?
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