Best Venous Disease Podcasts (2024)

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Ep. 15 - Understanding Peripheral Artery Disease: Causes, Symptoms, and Preventive Measures 20:16

3d ago20:16

20:16

In this episode of Cardiovascular Matters, Dr. Craig Walker and Terry Roberts delve into the critical topic of peripheral artery disease (PAD). They highlight the alarming prevalence of PAD, with an estimated 25 million Americans affected, and emphasize its deadly nature, noting that a person with a new PAD diagnosis is as likely to die of a heart …

1
Protective role of neonatal CMV infection in B-ALL; GVHD targets organoid-forming bile duct stem cells; seven-year outcomes for venetoclax-ibrutinib therapy in MCL 16:56

1h ago16:56

16:56

In this week's episode we'll learn how cytomegalovirus infection early in life depletes preleukemic cells in a mouse model of B-cell acute lymphoblastic leukemia. After that we'll discuss new research, where GVHD targets organoid-forming bile duct stem cells in a TGF-beta-dependent manner. Conversely, a TGF-beta inhibitor protects these stem cells …

1
Ep. 14 - Understanding & Managing High Blood Pressure: Men's health Preventative Screening Guide 16:48

4d ago16:48

16:48

In this in-depth podcast, cardiologist Dr. Craig Walker provides a thorough overview of high blood pressure (hypertension) - one of the leading risk factors for heart disease and stroke. Dr. Walker explains what blood pressure is and why it's important to control. He discusses the various causes of high blood pressure, including both primary (essen…

1
Iron, HFE haemochromatosis, and infections; bispecific antibodies improve CAR T-cell response; determinants of outcome in NPM1-mutated AML 23:31

1h ago23:31

23:31

In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro an…

1
Immune fitness and response to taclistamab in R/R multiple myeloma; BCR::ABL1 M244V mutation causes resistance to asciminib; HSCT and myocardial fibrosis in young patients with SCD 16:59

18d ago16:59

16:59

In this week's episode we’ll discuss how immune fitness impacts response to teclistamab in relapsed/refractory multiple myeloma; learn more about a new mechanism of resistance to asciminib conferred by the BCR::ABL1 M244V mutation, and discuss the impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell…

1
Decitabine in older patients with AML; EPCR and sickle chronic kidney disease; lymphocyte depletion versus post-transplant cyclophosphamide for mismatched donor transplant for inborn errors of immunity ... 22:53

19d ago22:53

22:53

In this week's episode we’ll discuss the safety and efficacy of decitabine in older patients with AML; learn how heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice, and discuss the outcomes of treatment with HLA-mismatched HSCT with TCRab/CD19 lymphocyte depletion or post-HSCT cyclophosph…

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Wound Healing and Burn Care 31:49

19d ago31:49

31:49

This episode of Surgical Readings features an informative conversation led by Rick Greene, MD, FACS, with the associate editors for the Wound Healing and Burn Care issue. Laura Haines, MD, FACS, and Deepak Bharadia, MBBS, FACS, provide valuable perspectives on the management of non-healing wounds, prevention of hypertrophic scarring, and achieving …

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Impact of MRD-negative on PFS in myeloma; IPSS-R down-staging before transplant in MDS; hereditary angioedema and venous thromboembolism 21:50

19d ago21:50

21:50

In this week's episode we'll discuss minimal residual disease as an intermediate clinical endpoint for multiple myeloma. Then, we'll learn about IPSS-R downstaging before transplant in MDS. Finally we'll hear about the connection between hereditary angioedema and venous thromboembolism. Featured Articles: EVIDENCE meta-analysis: evaluating minimal …

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Acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; alternative donor transplantation for severe aplastic anemia; clonal relapse dynamics in AML following allogeneic HCT 23:32

1M ago23:32

23:32

In this week's episode we’ll discuss the safety and efficacy of acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; learn more about alternative donor transplantation for severe aplastic anemia and discuss clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation. Featured Articles:…

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Clinical impact of CRh in AML; thrombosis features in a real-life PNH cohort; and restriction of SOX11 expression to EBV-negative Burkitt lymphomas 19:58

1M ago19:58

19:58

In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants o…

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Ep. 13 - Understanding PCSK9 Inhibitors for Cholesterol-Lowering: Men's health Preventative Screening Guide 12:08

1M ago12:08

12:08

Dr. Craig Walker and Terry Roberts discuss a new class of injectable cholesterol-lowering drugs called PCSK9 inhibitors. These medications provide an additional option for lowering LDL ("bad") cholesterol beyond statin therapy alone. Dr. Walker explains how PCSK9 normally works to block the recycling of LDL receptors in the liver, preventing furthe…

1
Mutational and transcriptional landscape of pediatric BCP lymphoblastic lymphoma; the role of platelet-derived TGF-1 in immune thrombocytopenia; phase 3 trial of mavorixafor in WHIM syndrome 23:25

2M ago23:25

23:25

In this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome. Featured Articles: Mutational and transcriptional landscape of pedi…

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Ep. 12 - Understanding Cholesterol-Lowering Medications: Men's health Preventative Screening Guide 19:31

1M ago19:31

19:31

Join Dr. Craig Walker as he provides an in-depth look at cholesterol-lowering medications, with a focus on statins. In this informative discussion, Dr. Walker breaks down the science behind these life-saving drugs, explaining how they work to reduce cholesterol production and increase its removal from the body. Learn about the two main types of sta…

1
GM-CSF coordinates shelter in the cytokine storm; Interleukin-1 as a therapeutic target in TTP; CAR T-cell outcomes across race and ethnicity in LBCL 19:57

2M ago19:57

19:57

In this week's episode we'll discuss new insights on the role of GM-CSF in establishing immune memory. The authors propose that the coordination of opposing immune memory programs, driven by GM-CSF, may be essential to efficient, yet controlled, innate immune responses. After that: Interleukin-1 inhibition in TTP. Researchers explore the potential …

1
Review Series on Oncogenic Signaling and Immune Evasion in Hematologic Malignancies 15:41

2M ago15:41

15:41

Introduced by Associate Editor Robert Zeiser, this Review Series focuses on the problem of immune escape by acute myeloid leukemia (AML). The series opens with a review of how AML escapes T-cell–driven elimination and then focuses on how p53 function impinges on AML recognition by immune cells. The series finishes with a summary of new approaches t…

1
Ep. 11 - Men's health Preventative Screening Guide: Don't Wait for Symptoms!! 33:02

2M ago33:02

33:02

In this episode of Cardiovascular Matters, Dr. Craig Walker discusses the importance of regular preventative health screenings for men to assess risk factors and detect early signs of cardiovascular disease. He recommends basic blood tests to check cholesterol levels, inflammation markers, and overall health. Additional tests like calcium scoring o…

1
Reassessing the CLL prognostic index; ADAMTS13 conformation and risk of relapse in immune-mediated TTP; haploidentical bone marrow transplant in sickle cell disease 23:39

2M ago23:39

23:39

In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase …

1
A biomarker for disease severity in Wiskott-Aldrich Syndrome; loss of Dnmt3a confers resistance to IFNα; unrelated donor selection in HSCT with PTCy 19:16

2M ago19:16

19:16

In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell tran…

1
Nilotinib with or without cytarabine for Philadelphia-positive AML; thrombosis risk in Factor V Leiden and Prothrombin G20210A; ctDNA improves prognostic prediction in relapsed/refractory multiple myeloma ... 23:05

2M ago23:05

23:05

In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in…

1
Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML 18:59

3M ago18:59

18:59

In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone…

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Ep. 10 - The Link Between Obesity and Chronic Disease: A Deeper Dive into SGLT2 Inhibitors 17:33

3M ago17:33

17:33

In this educational podcast, Dr. Walker discusses the latest research on a new class of diabetes drugs called SGLT2 inhibitors like Jardiance. He explains how these medications work by blocking glucose reabsorption in the kidneys, causing it to be excreted in urine. While initially developed and approved for diabetes, extensive clinical trials have…

1
Nutrition and Metabolic Disease 22:42

3M ago22:42

22:42

This episode focuses on important issues related to nutritional assessment and support in surgical patients. Host Rick Greene, MD, FACS, talks to Melissa Coleman, MD, and Joseph Rappold, MD, FACS, about nutritional assessment of critically ill patients, the role of nutrition in the management of a patient with esophageal cancer who is undergoing ne…

1
Effects of voxelotor on cerebral blood flow in pediatric sickle cell disease; thrombosis in Vexas syndrome; response to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia 22:26

3M ago22:26

22:26

In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia. Featured Articles: The influence of voxe…

1
Ep. 9 - The Obesity Epidemic and New Medication Options for Weight Loss 19:55

3M ago19:55

19:55

In this episode of the Cardiovascular Matters podcast, host Dr. Craig Walker discusses the growing problem of obesity in America and revolutionary new medication options that are helping people safely and effectively lose weight. Dr. Walker explains how obesity increases the risk of heart disease, diabetes and other serious health conditions. He th…

1
Stamping out high-risk myeloma with D-KRd and tandem transplant; plasmin-cleaved VWF in microthrombosis; SCD plasma sensitizes iPSC-derived sensory neurons 19:40

3M ago19:40

19:40

In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. Featured Articles: Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem…

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Ep. 8 - Understanding Obesity: Causes, Treatments and Prevention 20:14

3M ago20:14

20:14

This podcast discusses obesity as a major health problem and explores new medical treatments that are safe, effective and help patients feel better. The host Dr. Craig Walker and guest Terry Roberts discuss causes of obesity, health risks, challenges with past treatments and promising new medications. Terry Roberts provides context for the episode …

1
Allogeneic transplant in first remission for post-induction molecular MRD; circulating HSPCs actively participate in human hematopoiesis; let-7 miRNAs repress HIC2 to regulate BCL11A transcription and ... 21:44

3M ago21:44

21:44

In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcrip…

1
ADAMTS13 recovery in caplacizumab-treated TTP; inhibition of venetoclax-resistant BCL2 variants with sonrotoclax; genomic insights from Castleman disease in twins 19:10

4M ago19:10

19:10

In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researche…

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Ep. 7 - Post-Procedure Care and Follow Up for Venous Disease Treatments 18:05

4M ago18:05

18:05

In this episode of Cardiovascular Matters, Dr. Craig Walker discusses the post-procedure care and follow up for patients who have undergone treatments for venous disease. He covers different types of procedures like stenting of the iliac veins, removal of deep vein clots, and closure of superficial and perforator veins. Dr. Walker explains the reco…

1
Durable response after tisa-cel in adults with relapsed/refractory follicular lymphoma; high microRNA-145 plasma levels indicate decreased risk of VTE; epigenetic/immunogenetic signature in the prediction ... 23:49

4M ago23:49

23:49

In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and …

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Ep. 6 - Understanding Perforator Veins and Their Role in Non-Healing Ulcers 14:28

4M ago14:28

14:28

This episode of Cardiovascular Matters explores perforator veins and their role in non-healing leg ulcers with Dr. Craig Walker. Dr. Walker discusses how perforator veins connect deep and superficial leg veins, and how they can cause high pressure that prevents ulcer healing. Perforator veins are connections between deep and superficial leg veins T…

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Gut microbiota exploitation by CPX-351 in AML; optimizing anti-myeloma immunity for ASCT; which pediatric ITP patients will develop lupus? 19:00

4M ago19:00

19:00

In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients wi…

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Ep. 5 - Do you have peripheral artery disease? And does it matter? 14:31

5M ago14:31

14:31

Welcome to Cardiovascular Matters, a podcast dedicated to discussing all aspects of cardiovascular health and disease. Today we're joined by Dr. Craig Walker, a leading cardiologist and expert in peripheral artery disease. Dr. Walker will help us understand what PAD is, who is affected, and why early detection and treatment is so important for over…

1
Jak2V617F clonal hematopoiesis promotes arterial thrombosis; Staphylococcus aureus infection in Sézary syndrome; clinical features of RAC2-related immunodeficiency 26:18

4M ago26:18

26:18

In this week's episode we’ll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency. Featured Articles: Jak2V617F clonal hemat…

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Ep. 4 - What is a Pulmonary Embolism? A Guide to Diagnosis and Life-Saving Treatments 17:10

5M ago17:10

17:10

In this informative episode of the Cardiovascular Matters podcast, host Dr. Craig Walker sits down with his colleague Terry Roberts to discuss pulmonary embolisms (PEs) in comprehensive detail. PEs, which occur when blood clots travel to the lungs, are a serious cardiovascular condition that can quickly become life-threatening if not properly diagn…

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Molecular mimicry in aplastic anemia; emicizumab prophylaxis in infants with hemophilia; hydroxyurea reduces infections in SCA 19:54

4M ago19:54

19:54

In this week's episode we'll discuss molecular mimicry in aplastic anemia, novel experiments show that antigens associated with viral infections can mimic epitopes presented on hematopoietic progenitor cells. Then, we'll learn about prophylaxis with subcutaneous emicizumab in infants with hemophilia. Finally we'll see how hydroxyurea is associated …

1
Ep. 3 - Healing Venous Ulcers: New Hope Through Minimally Invasive Procedures 17:39

5M ago17:39

17:39

Have you or a loved one struggled with painful, persistent venous ulcers? In this episode of Cardiovascular Matters, Dr. Craig Walker sheds light on venous disease - a common condition that often goes undiagnosed and untreated. Dr. Walker's interest in venous issues began early in his career while working to open blocked arteries and access the hea…

1
Review Series on the Influence of the Tumor Microenvironment on the Pathogenesis of B-Cell Lymphomas 32:05

5M ago32:05

32:05

In this bonus episode of Blood Podcast, Associate Editor, Dr. Freda Stevenson is joined by Drs. Karin Tarte, Andrea Radtke, and Leandro Cerchietti to discuss the Review Series on the influence of the tumor microenvironment on the pathogenesis of B-cell lymphomas. Find the full review series in Blood Journal volume 143 issue 12.…

1
Free light chain mass spectrometry in diagnosis and monitoring of AL amyloidosis; T cells of AML patients in remission have distinct RNA signatures; and protective effect of ADAMTS13 in sickle cell mice ... 22:34

5M ago22:34

22:34

In this week's episode we’ll discuss the findings from a study assessing the utility of free light chain mass spectrometry in AL amyloidosis, learn more about distinct single-cell RNA-sequencing signatures of bone marrow T cells of AML patients in remission after an allogeneic stem cell transplant, and discuss why von Willebrand factor clearance is…

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Ep. 2 - Varicose Veins: Getting to the Root of Venous Issues: Iliac Vein Compression and Beyond 23:09

5M ago23:09

23:09

Dr. Craig Walker and Terry Roberts discuss varicose veins and other venous disorders on this episode of Cardiovascular Matters. They delve deeper into obstructive venous disorders like iliac vein compression syndrome, also known as May-Thurner syndrome In this episode, Dr. Walker sits down with host Terry Roberts to explore causes of venous obstruc…

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Eculizumab in transplant-associated thrombotic microangiopathy; reclassifying malignant monocytosis; targeting tissue factor in antiphospholipid syndrome 20:50

5M ago20:50

20:50

In this week's episode we'll discuss eculizumab in stem cell transplant-associated thrombotic microangiopathy. Then, we'll learn about reclassifying malignant monocytosis, these newly classified cases have distinct mutational and transcriptional profiles. Finally, we'll hear about targeting the tissue factor coagulation initiation complex prevents …

1
Identification of rare relapse-initiating stem cells post-transplantation; interferon α impairs erythropoiesis in sickle cell disease; TNFα promotes clonal dominance of KIT D816V+ cells in mastocytosis ... 22:48

5M ago22:48

22:48

In this week's episode we’ll learn more about rare relapse-initiating stem cells in patients with MDS or AML in complete remission post-transplantation, discuss the role of interferon α in erythropoiesis in sickle cell disease, and learn more about how TNFα promotes clonal dominance of KIT D816V+ cells in mastocytosis.…

1
Ep. 1 - Understanding Varicose Veins: A Comprehensive Look at Causes, Symptoms and Treatments 33:26

6M ago33:26

33:26

In the premiere episode of Cardiovascular Matters, hosts Dr. Craig Walker and Terry Roberts delve into a comprehensive explanation of varicose veins and venous insufficiency. Dr. Walker begins by providing context on the prevalence of venous disease, affecting over half of Americans. However, it is often misunderstood due to a lack of public educat…

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How PAR2 signaling drives thrombo-inflammation; pretransfusion hemoglobin levels linked to survival in beta-thalassemia; etoposide is better than its reputation in primary HLH 17:48

6M ago17:48

17:48

In this week's episode we'll discuss PAR2-biased signaling in thrombo-inflammation. Then, we'll learn about how hemoglobin levels are linked to survival in transfusion-dependent beta-thalassemia. Finally we'll hear about how etoposide is better than its reputation in primary HLH—hemophagocytic lymphohistiocytosis. Symptomatic patients treated with …

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Surgical Site Infections: Antimicrobial Therapy, Source Control, and Prevention 17:36

6M ago17:36

17:36

In this episode host Rick Greene, MD, FACS, talks to Lillian Kao, MD, FACS, from The University of Texas, Houston McGovern School of Medicine, about prevention and treatment of surgical site infections. Topics covered include bacterial resistance to antimicrobial drugs, novel therapies on the horizon, and lessons learned from viruses such as COVID …

1
Brentuximab vedotin plus dacarbazine or nivolumab in classical Hodgkin lymphoma; loss of CD20 causes resistance to mosunetuzumab in r/r B-cell lymphomas; trogocytosis as a driver of RBC antigen loss 23:02

6M ago23:02

23:02

In this week's episode we’ll discuss the findings from a prospective trial of brentuximab vedotin with dacarbazine or nivolumab in older patients with classical Hodgkin lymphoma, learn more about CD20 antigen loss as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas, and discuss the role of trogocytosis in red blood…

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CAR T cells plus ibrutinib in relapsed/refractory MCL; targeting SGF29 in AML; diffusion-limited oxygen release from stored blood 18:50

6M ago18:50

18:50

In this week's episode we'll discuss CAR T cells plus ibrutinib for the treatment of relapsed/refractory mantle cell lymphoma. Next, we'll learn about a new SAGA for acute myeloid leukemia. Finally, we'll hear about new evidence that oxygen delivery to tissues can become diffusion-limited during perfusion with stored blood.…

1
Long-term outcomes of pulmonary embolism in children and adolescents; hereditary angioedema caused by a methionine-379 to lysine substitution in kininogens; predictors of loss of MRD negativity in multiple ... 25:07

6M ago25:07

25:07

In this week's episode we’ll report on the findings from a study evaluating the long-term outcomes of pulmonary embolism in children and adolescents, discuss a new mechanism for hereditary angioedema caused by a methionine-379 to lysine substitution in kininogens, and learn more about predictors of unsustained minimal residual disease negativity in…

1
Extended follow-up of axi-cel in indolent NHL; platelets help clear senescent RBCs; novel risk stratification strategy for CNS lymphoma 18:58

6M ago18:58

18:58

In this week's episode we'll discuss extended follow-up from the ZUMA-5 trial of axicabtagene ciloleucel, or axi-cel. Then we'll learn about the role of platelets in binding and clearing senescent red blood cells. Finally, we'll hear about a new risk stratification strategy for lymphomas of the central nervous system, or CNS.…

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Lisocabtagene maraleucel in relapsed or refractory large B-cell lymphoma; reciprocal stabilization of coagulation factor XIII-A and -B subunits; inotuzumab ozogamicin for MRD in ALL 22:26

7M ago22:26

22:26

In this week's episode we’ll discuss the findings from a two-year follow-up study of lisocabtagene maraleucel in relapsed or refractory large B-cell lymphoma, learn more about how reciprocal stabilization of coagulation factor XIII-A and -B subunits influences plasma FXIII concentration, and discuss the findings from a phase 2 study of inotuzumab o…

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Venous Disease Podcasts

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