This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.
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EP-EDGE brings you the latest in cardiac electrophysiology — from breakthrough research and clinical insights to future-shaping innovations. Hosted by Dr. Niraj Sharma, an electrophysiologist with over 15 years of experience, each episode delivers clear, evidence-based updates designed to inform, inspire, and elevate your practice.
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Welcome to EP Edge Journal Watch — where cardiac electrophysiology meets evidence, precision, and perspective. Hosted by Dr. Niraj Sharma, this bi-weekly podcast distills high-impact cardiovascular and EP research into clear, clinically meaningful insights. Each episode goes beyond headlines and abstracts to uncover what new studies actually mean for patient care, decision-making, and the future of electrophysiology. What EP Edge Journal Watch stands for: Evidence-based practice Precision el ...
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This Big Blend Radio health podcast features Dr. Jacqueline Eubany, a board-certified cardiologist and electrophysiologist, and author of the best-selling book, “Women and Heart Disease: The Real Story.” New episodes air every 2nd Wednesday at 12pm PST.
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Natural Medicine Journal's interviews with thought-leaders in the field of natural and integrative medicine dig deep into the most important topics in the field. Whether it's a one-on-one with top researchers in integrative medicine or a conversation with a practitioner about treating hard-to-tackle conditions, each episode promises to provide trusted, cutting-edge, evidence-based knowledge about natural medicine that you won't find anywhere else.
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Lifestyle Modification and Atrial Fibrillation: Redefining the role of the Electrophysiologist: EP Edge Newsletter July 2025
14:59
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14:59Ablation is powerful—but lifestyle is transformative. As atrial fibrillation (AF) continues to rise globally, emerging evidence makes it clear: lifestyle modification is not just complementary care, it’s frontline therapy. In this episode of EP Edge, Dr. Niraj Sharma explores how structured lifestyle interventions—targeting weight, alcohol use, sle…
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Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https…
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EP Edge Journal Watch — November 2025, Edition 2: From Lifestyle to Lifeline
16:41
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16:41In this episode, Dr. Niraj Sharma breaks down six pivotal studies shaping today’s electrophysiology and cardiology practice—from lifestyle-driven AF control (ARREST-AF) and post-CABG atrial fibrillation management to the DOAC + aspirin conundrum in stable CAD, the return of digitoxin in HFrEF, insights from CABANA-Substudy, and the latest ICD regis…
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Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://…
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EP Edge Journal Watch | Episode 1, November 2025: Potassium and VT, GDMT Withdrawal & AF Risk Uncovered
12:35
12:35
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12:35In this inaugural episode, Dr. Niraj Sharma breaks down three pivotal studies that could shift daily EP practice: How high-normal potassium targeting can reduce VT burden (POT-CAST trial). When GDMT withdrawal may be safe after recovery from tachycardia-induced cardiomyopathy. Why adverse pregnancy outcomes may predict long-term AF risk. Get the si…
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Targeting the Intrinsic Pathway: Is Factor XI Inhibition Poised to Redefine Stroke Prevention in AF: EP Edge August 2025 Issue 4A
10:22
10:22
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10:22What if stroke prevention in atrial fibrillation no longer meant trading protection for bleeding risk? Factor XI inhibition—led by trials like AZALEA–TIMI 71, LILAC–TIMI 76, and LIBREXIA–AF—is poised to rewrite the anticoagulation playbook. By targeting the intrinsic pathway, these agents may decouple thromboembolic protection from major bleeding, …
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First-Line VT Ablation: Trials, Tools & Timing: EP Edge Newsletter June 2025
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8:05The paradigm is shifting. Ventricular tachycardia (VT) ablation is stepping out of the shadows—from rescue therapy to first-line strategy, driven by landmark trials like VANISH2, PAUSE-SCD, and PARTITA. Meanwhile, pulse field ablation (PFA) continues its rapid evolution—crossing over from atrial to ventricular applications—but questions about durab…
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Left Atrial Appendage Occlusion (LAAO): Where We Stand in 2025: EP Edge Newsletter 4B August 2025
9:14
9:14
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9:14Left atrial appendage occlusion (LAAO) has evolved from a niche option for oral anticoagulation–intolerant patients to a frontline procedural strategy for stroke prevention in atrial fibrillation. Landmark trials like OPTION, SWISS‑APERO, and COMBINATION are redefining how and when we use these devices. In this episode of EP Edge, Dr. Niraj Sharma …
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Pulse Field Ablation: Promise, Peril, and the AI Revolution in EP: EP Edge Newsletter May 2025
9:22
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9:22Pulse field ablation (PFA) has been hailed as the next frontier in atrial fibrillation therapy—nonthermal, ultra-selective, and lightning fast. But as new data emerges, important questions are rising about its systemic effects, cerebral safety, and vascular complications. In this episode of EP Edge, Dr. Niraj Sharma unpacks the latest findings from…
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Beyond CRT: LBBAP and the New Era of Physiological Pacing — Promise and Pitfalls: EP Edge Newsletter October 2025 Issue 5
10:31
10:31
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10:31In this episode of EP Edge Podcast, Dr. Niraj Sharma dives deep into the clinical promise and procedural realities of LBBAP: Clinical advantages: improved LVEF, narrower QRS, lower VT/VF and AF incidence. RV protection: reduced risk of pacing-induced cardiomyopathy. Sex-specific outcomes: women with NICM + LBBB derive greater benefit. Complications…
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The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…
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Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or…
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GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…
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Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: …
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A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a few public service announcements are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to com…
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More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.med…
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More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed by John Mandrola, MD. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I New European Valvular Heart Disease …
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This episode of Big Blend Radio’s “Heart Healthy Living with Dr. Jackie” Podcast observes National Peripheral Artery Disease Awareness Month withb oard-certified cardiologist Dr. Jacqueline Eubany, author of “Women and Heart Disease: The Real Story,” who discusses the critical connection between peripheral vascular disease (PVD) and heart health. T…
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The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/t…
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CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I CAC 0 LDL-C and CVD Risk With CA…
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Youth and Heart Disease: A Growing Concern
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25:37Big Blend Radio’s “Heart Healthy Living with Dr. Jackie” Podcast In recognition of National Wellness Month and Back to School season, board-certified cardiologist Dr. Jacqueline Eubany—author of “Women and Heart Disease: The Real Story” —shines a light on the alarming rise of heart disease among younger generations. The conversation explores key ri…
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John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Conduction System Pacing CSPACE trial https://doi.org/10.1016/j.ja…
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Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:…
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Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape…
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Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that caused harm in veterans are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https:…
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The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.…
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In celebration of International Self-Care Day, board-certified cardiologist Dr. Jacqueline Eubany—author of “Women and Heart Disease: The Real Story”—explores why self-care is essential for heart health. From the importance of sleep and mindfulness to the evolving role of AI in healthcare, this episode offers practical and empowering ways to priori…
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Finerenone, what not to consider when choosing treatment of AS, brain health after atrial fibrillation ablation, early rhythm control for AF, and Watchman reimbursement cuts are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https…
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Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), and some thoughts on the end of EP as a profession are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial tran…
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Heart Health on the Go: Travel Safety Tips and Summer Wellness
30:34
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30:34In this “From the Vault” episode of Big Blend Radio’s Heart Healthy Living with Dr. Jackie, we celebrate Parks & Recreation Month and the Summer Travel Season with an essential conversation on heart health during travel and outdoor adventures. Board-certified cardiologist Dr. Jacqueline Eubany highlights the importance of recognizing heart attack s…
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FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes care is on fire are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://…
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