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Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations w ...
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Insightful conversations with leading experts in the field of health care, medical research, policy, and more from the New England Journal of Medicine (NEJM). Each episode examines the many complexities found at the junction of medicine and society.
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This podcast from NEJM Catalyst features interviews with leaders in health care as they discuss innovative ideas and actionable solutions for enhancing the value of health care delivery, providing perspectives on what's working in the industry, what's not, and why.
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This podcast from NEJM Resident 360 takes a deep dive into key topics with expert clinicians and educators. As we explore the details of pathophysiology and critique the evidence behind clinical practice, these conversations are intended to give you better understanding of the topic and greater confidence when treating your patients.
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Time Stamps 00:00 Introduction 02:28 Pathophysiology of Colorectal Cancer & Why Screening Makes Sense 06:15 General Cancer Screening – Observational Studies 09:17 General Cancer Screening – Randomized Controlled Trials 14:40 NordICC Trial 22:36 Implications for Patient Care Sponsor: At Panacea Financial, you get a personal banker and a competitive …
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Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on screening colonoscopies before NordICC trial, even though it is a guideline based recommendation for everyone over 45! How did this come to be? What do we tell our patients who are on the fence about undergoing screening colonoscopy?…
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Jessica Lewis is a research scientist at the Yale School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.B. Lewis and J.R. Ickovics. Expect With Me — Group Prenatal Care to Reduce Disparities. N Engl J Med 2024;390:2039-2040.
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Nathaniel Chin is an associate professor in the Division of Geriatrics and Gerontology and medical director of the Alzheimer's Disease Research Center at the University of Wisconsin School of Medicine and Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. N.A. Chin and C.M. Erickson. Alzheimer’s Dise…
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Featuring articles on treatments for eosinophilic esophagitis, reteplase versus alteplase for acute ischemic stroke, dupilumab for COPD with type 2 inflammation, and brigatinib in NF2-related schwannomatosis; a review article on amyloidosis; a case report of a man with recurrent fever and liver lesions; and Perspectives on Alzheimer’s disease, biom…
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Christine Grady is chief of the Department of Bioethics at the National Institutes of Health Clinical Center. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S. Hendriks and C. Grady. Ethics and Highly Innovative Research on Brain Diseases. N Engl J Med 2024;390:2133-2136.…
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Featuring articles on combination therapy for diffuse large B-cell lymphoma, autosomal dominant Alzheimer’s disease, noninvasive ventilation for preoxygenation during emergency intubation, a novel anti-CD38 antibody in immune thrombocytopenia, and a glucose-responsive insulin for type 2 diabetes; a review article on congenital and acquired Chiari s…
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In this episode of the AI Grand Rounds podcast, Dr. Adam Rodman shares his unique journey from a historian to a physician deeply interested in the intersection of medicine and artificial intelligence. He highlights his unconventional path, driven by an obsession with epistemology and nosology, and his early exposure to AI through historical referen…
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Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty.…
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Featuring articles on neoadjuvant immunotherapy for dMMR colon cancer, TAVR in patients with a small aortic annulus, gene editing and retinal degeneration, and the genetic diagnosis of rare diseases; a review article on disorders of magnesium; a case report of a woman with metastatic breast cancer; and a Perspective on malicious midwives, fruitful …
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Time Stamps 01:59 Pearl 1 – What is HFpEF? 11:22 Pearl 2 – Echo findings and diastolic dysfunction 19:21 Pearl 3 – BNP 25:06 Pearl 4 – Advanced Testing 32:03 Pearl 5 – Treatments for HFpEF CME-MOC Get CME-MOC credit with ACP! Sponsor: Freed is an AI scribe that listens, prepares your notes, and writes your note in < 30 seconds. Freed learns your st…
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What causes HFpEF? (1:59) Does diastolic dysfunction imply HFpEF? (11:22) Is the BNP level helpful in HFpEF? (19:21) What scoring systems can be helpful in ruling in HFpEF? (25:06) What's the treatment for HFpEF? (32:03) Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA …
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Katharine Silbaugh is a professor at the Boston University School of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Silbaugh, L. Del Valle, and C. Robertson. Toward a Tobacco-free Generation — A Birth Date–Based Phaseout Approach. N Engl J Med 2024;390:1837-1839.…
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Featuring articles on aficamten for obstructive hypertrophic cardiomyopathy; early blood-pressure reduction in acute stroke; interferon-γ in autoimmune polyendocrine syndrome type 1; video laryngoscopy for intubation in neonates; hunger, thirst, and Buridan’s ass; and global health law for a safer and fairer world; a review article on medical AI an…
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Previous Next Time Stamps 01:56 Pearl 1: Mechanism of checkpoint inhibitors and their adverse events 07:15 Pearl 2: Organ systems affected by IRAEs 13:42 Pearl 3: Timeline of IRAEs 22:20 Pearl 4: Factors which increase susceptibility 26:38 Pearl 5: Complementary medicine Sponsor: At Panacea Financial, you don’t need co-signers for personal loans an…
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How do immune checkpoint inhibitors work? (01:56) How do you organize the different immune-related adverse events (irAEs)? (07:15) Generally, when do different adverse events can present? (13:42) What makes someone more likely to develop an adverse effect? (22:20) What role does complementary & alternative medicine play in this patient population? …
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Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Demetre Daskalakis is the Director of the CDC’s National Center for Immunization and Respiratory Diseases. Hilary Marston is the Chief Medical Officer of the Food and Drug Administration. Stephen Morrissey, the interviewer, is the Executive Managing E…
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Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Jeanne Marrazzo is the director of the National Institute of Allergy and Infectious Diseases. Arnold Monto is emeritus professor of public health at the University of Michigan. Stephen Morrissey, the interviewer, is the Executive Managing Editor of th…
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Alicia Fernandez is a professor of medicine at the University of California, San Francisco. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A. Fernandez and M.H. Chin. Keep Your Eyes on the Prize — Focusing on Health Care Equity. N Engl J Med 2024;390:1733-1736.
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Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective article…
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In this episode of the NEJM AI Grand Rounds podcast, Dr. Nigam Shah, a distinguished Professor of Medicine at Stanford University and inaugural Chief Data Scientist for Stanford Health Care, shares his journey from training as a doctor in India to becoming a leading figure in biomedical informatics in the United States. He discusses the transformat…
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Urinalysis in a patient with AKI from purely cardiorenal syndrome? (~02:05) What is bioavailability, duration of action, and outcomes with furosemide, torsemide, and bumetanide? (~08:47) How can spot urine sodium measurements be used to assess diuretic response? (~18:08) What are the differences between thiazides (PO Metolazone vs. IV Chlorothiazid…
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Joshua Sharfstein is distinguished professor of the practice in health policy and management at the Johns Hopkins Bloomberg School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.M. Sharfstein and L.O. Gostin. The Public Good on the Docket — The Supreme Court’s Evolving Approach to Public Hea…
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Featuring articles on gene editing in severe sickle cell disease and in transfusion-dependent β-thalassemia, thrombectomy for stroke with a large infarct, and recombinant ADAMTS13 in life-threatening immune thrombotic thrombocytopenic purpura; a review article on taste physiology; a case report of a woman with back pain, leg stiffness, and falls; a…
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Featuring articles on a monoclonal antibody to prevent malaria, apolipoprotein A1 and outcomes after myocardial infarction, transcatheter or surgical treatment of aortic-valve stenosis, and recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura; a review article on cryptococcal disease in diverse hosts; a Clinical Problem-Solving on…
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Kevin Schulman is a professor of medicine at the Stanford University School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Schulman and B. Richman. Hospital Consolidation and Physician Unionization. N Engl J Med 2024;390:1445-1447.
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Featuring articles on empagliflozin after acute myocardial infarction, CD7 CAR T cells with allogeneic stem-cell transplantation, FFR-guided complete revascularization for STEMI, and nutrition for moderate-to-late preterm infants; a review article on age-related hearing loss; a case report of a man with leg weakness; and Perspective articles on hos…
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