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Episode 11: The Unique Nature of This Virus: HHV-6
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German virologist, Dr. Bhupesh Prusty, discusses his research on the human herpes virus, HHV-6, and its important role in many medical conditions including DRESS syndrome.
We then hear from Japanese dermatologist and DRESS expert, Dr. Hideo Asada, about the long-term complications associated with HHV-6 and DRESS.
Interview: Dr. Bhupesh Prusty (Molecular virologist University of Wuerberg, Germany), Dr. Hideo Asada (Professor, Researcher at the Department of Dermatology Nara Medical University in Japan), June, 2019 in Quebec, Canada
PUBLICATIONS/RESOURCES:
Dr. Bhupesh Prusty:
Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report: https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3680?af=R
HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation: https://www.nature.com/articles/s41525-018-0064-5
Additional Publications/Researchgate: https://www.researchgate.net/profile/Bhupesh-Prusty
Dr. Hideo Asada:
Dynamics of chemokines in severe drug hypersensitivity: https://ctajournal.biomedcentral.com/articles/10.1186/2045-7022-4-S3-P29
Parallel changes in serum thymus and activation‐regulated chemokine levels in response to flare‐ups in drug‐induced hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/pdf/10.1111/1346-8138.15548
Preferential expression of CD134, an HHV-6 cellular receptor, on CD4T cells in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): https://hhv-6foundation.org/transplant-complications/cd134-upregulation-may-explain-why-hhv-6-reactivates-preferentially-in-dress
Facial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: A case report: https://pubmed.ncbi.nlm.nih.gov/30666704/
Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR): https://pubmed.ncbi.nlm.nih.gov/25623158/
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms or non-drug-related erythroderma with a persistent human herpesvirus 6 infection: https://doi.org/10.1111/1346-8138.15145
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