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Episode 4: The Link Between Viruses and Severe Adverse Drug Reactions: A Discussion with the Experts
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International severe adverse drug reaction experts, Dr. David Ostrov and Dr. Vincent Descamps, talk to us about the immune response that occurs in DRESS syndrome as well as how antiviral and steroid therapies are often indicated in fighting this condition.
We also hear from Kent Van Donge about the importance of a team approach in the treatment of DRESS.
Interview: Dr.David A.Ostrov (Associate Professor of Experimental Pathology/University of Florida), Dr. Vincent Descamps (Professor of Dermatology at Bichat Claude Bernard Hospital), Kent Van Donge (Intern/Student and EMT) at the HHV-6 Foundation 2019 Conference in Quebec, Canada.
PUBLICATIONS/RESOURCES:
Dr. David Ostrov:
David A. Ostrov Laboratory: https://ostrovlab.pathology.ufl.edu/about-dr-ostrov/
The structural basis of HLA-associated drug hypersensitivity syndromes: https://onlinelibrary.wiley.com/doi/10.1002/ccr3.3680#.X90Agxjv1sI.twitter
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire:https://www.pnas.org/content/109/25/9959.long
Full List of Publications: https://ostrovlab.pathology.ufl.edu/about-dr-ostrov/select-publications/full-list-of-publications/
Dr. Vincent Descamps:
DRESS syndrome:https://docs.wixstatic.com/ugd/cac731_643993b7381f4c85b7d4b62dce42087b.pdf
Diagnosis of DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) in the Intensive Care Unit: Essential But Challenging: https://journals.lww.com/shockjournal/Fulltext/2013/11000/Diagnosis_of_DRESS__Drug_Reaction_With.14.aspx
French dermatologists call for antiviral therapy in DRESS:https://hhv-6foundation.org/drug-hypersensitivity/french-dermatologists-call-for-antiviral-therapy-in-dress
Saliva polymerase chain reaction assay for detection and follow-up of herpesvirus reactivation in patients with drug reaction with eosinophilia and systemic symptoms (DRESS): https://pubmed.ncbi.nlm.nih.gov/23426332/
Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelatez: https://pubmed.ncbi.nlm.nih.gov/23361875/
Human herpesvirus 6 involvement in paediatric drug hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.13592
The DRESS Syndrome: A Literature Review: https://www.amjmed.com/article/S0002-9343(11)00258-0/fulltext
Service de Dermatologie/Hôpital Bichat - Claude-Bernard:https://www.aphp.fr/service/service-16-011
Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s-like colitis. Case report:
https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3680?af=R
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