#92 – Antibiotic Alchemy: Metallo-Beta-Lactamases

Breakpoints

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4M ago 1:10:30

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Drs. Robert Bonomo, Ryan Shields (@ryankshields), and Erin McCreary (@ErinMcCreary) deep dive into the world of metallo-beta-lactamases. This riveting discussion is full of the nerdiest pub trivia nuggets and the “must know” details of novel beta lactams and beta-lactamase inhibitors, and their uses for MBLs. Funding for this podcast was provided by Shionogi Inc.

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References:

Urgent need for metallo B lactamase: DOI: 10.1016/S1473-3099(20)30868-9
NDM-9 Resistance to Taniborbactam: DOI 10.1016/S1473-3099(23)00069-5
AAC Taniborbactam inhibition of NDM-1: DOI 10.1128/aac.01332-23
OFID NDM E. coli with cefiderocol and aztreonam/avibactam resistance: DOI 10.1093/ofid/ofad276

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