The History and Future of CAR T with Bruce Levine

Raising Health

#Tech #Andreessen Horowitz #Academia #Engineering #Future #Healthcare #Biology #Science #Natural Sciences #A16z

50:30

Episode Notes [00:00] The Importance of Questioning [01:21] Introduction to Curated Questions [02:20] Meet Kevin Kelly [03:56] Kevin Kelly's Mentor: Stewart Brand [05:33] The Role of Questions in Intellectual Traditions [06:47] Disequilibrium and Growth [10:21] Embodied Questions and Exploration [11:11] Balancing Exploration and Exploitation [11:50] The Inefficiency of Questioning [15:53] The Abundance Mindset [18:39] The Inevitable and Quality Questions [19:26] Hill Climbing vs. Hill Making [22:28] The Challenge of Innovation [24:13] The Beauty of Engineering and Innovation [24:34] Navigating the Frontier of New Technologies [25:33] The Role of AI in Question Formulation [26:43] Challenges in Advancing AI Capabilities [29:11] The Long Now Foundation and the 10,000 Year Clock [29:56] Transmitting Values Over Time [31:03] Ethics in AI and Self-Driving Cars [33:26] The Art of Questioning [34:04] Photography: Capturing vs. Creating [36:12] The Inefficiency of Exploration [38:36] Daily Practice and Long-Term Success [40:17] The Importance of Quantity for Quality [43:22] Final Thoughts and Encouragement on Questioning [46:24] Summary Takeaways Resources Mentioned Wired Magazine Whole Earth Review WELL Hackers Conference What Technology Wants by Kevin Kelly The Inevitable by Kevin Kelly Cool Tools Project Long Now Foundation Stewart Brand Socratic Method Koan René Descartes Conde Nast Vouge Olivetti Typewriter Trolley Problem Terry Gross Lex Friedman Tim Ferriss KK.org Kevin2Kelly on Instagram Recomendo Newsletter Excellent Advice for Living Beauty Pill Producer Ben Ford Questions Asked When did you first understand the power of questions? Can I do that? Can that be something that you can learn? How did questions function differently between Eastern versus Western intellectual traditions? What role do you think embodied questions those we explore through doing rather than thinking play in developing wisdom? What's on the other side of the hill? What happens if you go to the end? What's the origin of this? How should one think about the exploratory in one's life? Is there anything that you would add to your list of 15 statements that define what makes a quality question? Is there a qualitative difference between the questions humans are asking and the questions our AI systems are beginning to formulate? What do you think would help them get there? Any idea on a forcing function on how we get them [LLMs] to ask the better questions so that they might improve in that direction? What were some novel questions that broke your brain at the time in thinking about this 10,000-year clock or beyond? What's it good for? What would you use it for? What else could you do over the long term for 10,000 years? How do you transmit values over time? How do you evolve values that need to change, and how do you make a difference? How do even know what you don't want to change? What do you want to continue? What's the most essential aspects of our civilization that we don't want to go away? What are the rules? What is the system? How do you pass things along in time and not change the ones you don't wanna change, and make sure you change the ones that are more adaptable so they can adapt? What do you think about questioning itself as an art form? How has being a photographer influenced the way you question reality, visually compared to verbally? Are you a photographer that takes photos or makes photos? What will happen? What will happen next? What are your right now questions that you are wrestling with or working with in your life? Can someone else do what I'm trying to do here? Am I more me in doing my art or more me in doing the writing? Do you have any other thoughts or encouragement about questions that we haven't explored? What makes a good question? How do you ask a good question? What questions do you dwell on to be in purposeful imbalance? What is your practice in embracing the inefficient nature of questions to achieve breakthroughs? What are the new hills you can build and frontiers you can explore? How can you use your curiosity and humanity to pursue questions that trend toward the fringes?…

about a year ago 31:26

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Bruce Levine, PhD, the Barbara and Edward Netter Professor in Cancer Gene Therapy at the University of Pennsylvania, joins Jorge Conde, general partner, and Ginger Liau, partner at a16z Bio + Health.

Bruce talks about how his time working in a lab at the Children’s Hospital of Philadelphia inspired him to work on translational therapies. Together, they also discuss barriers to access for cancer therapeutics and how the fight against cancer is progressing.

Additional disclosures for Bruce include:

Scientific Advisory Boards: Avectas, Capstan (Chair), Immuneel, Immusoft, In8bio, Ori Biotech, Oxford Biomedica, ThermoFisher Pharma Services, UTC Therapeutics. Scientific Advisor: Kite. Past: Akron, Vycellix

Co-Founder and equity holder: Tmunity Therapeutics (acquired by Kite), Capstan Therapeutics

Board of Directors: Alliance for Cancer Gene Therapy

Conflict of interest is managed in accordance with University of Pennsylvania policy and oversight.

181 episodes

The History and Future of CAR T with Bruce Levine

Raising Health

10,705 subscribers

published about a year ago

MP3•Episode home

Bruce Levine, PhD, the Barbara and Edward Netter Professor in Cancer Gene Therapy at the University of Pennsylvania, joins Jorge Conde, general partner, and Ginger Liau, partner at a16z Bio + Health.

Additional disclosures for Bruce include:

Co-Founder and equity holder: Tmunity Therapeutics (acquired by Kite), Capstan Therapeutics

Board of Directors: Alliance for Cancer Gene Therapy

Conflict of interest is managed in accordance with University of Pennsylvania policy and oversight.

181 episodes

#Tech #Andreessen Horowitz #Academia #Engineering #Future #Healthcare #Biology #Science #Natural Sciences #A16z

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