Psychedelic-Assisted Therapy: MDMA

The Soul of Life

This episode is a "best-of" replay from S1 of The Soul of Life. In this episode of The Soul of Life I speak with Dr. Michael Mithoefer, the lead investigator that has successfully piloted the first-ever study of MDMA, otherwise known as ecstasy, into the third and final stage of FDA approval for the treatment of post-traumatic stress disorder.

Dr. Mithoefer is featured as a lead character in the 2015 book Acid Test by award-winning journalist Tom Shroder, a meticulously researched history of the controversy and unprecedented healing properties associated with psychedelics.

The FDA granted Dr. Mithoefer and his colleagues “breakthrough status” to expedite its application for approval because they’re seeing such dramatic results working with veterans tormented by complex PTSD which is notoriously difficult to treat even with the best and most expensive therapies.

“We’ve had people with uncontrollable rage just have that stop happening after one session.”

I talk with Michael about the safety of therapeutically-supervised MDMA and how it works in the brain. MDMA is referred to as an “empathogen,” because it activates our natural ability to be openhearted, friendly, and collaborative, something that immediately gets switched off when the brain goes into safe mode while experiencing emotional turmoil—even garden variety stress can do this, like a parent that yells every day, or a boss that expects to get perfection but only gives criticism.

But for now, Dr. Mithoefer is using particularly egregious forms of trauma—combat experience—as the test use case with the FDA. And unlike many people’s idea of all illegal drugs being dangerous or addictive, a full course of MDMA is given in micro-doses only 2-3 times in about a month—accompanied by an all-day psychotherapy session each time—but the patient essentially walks away born-again. They report seeing the world not just the way it was before their trauma but with eyes that are profoundly capable of seeing gratitude, joy and meaning in life.

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