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Is Prazosin Effective for PTSD? Depends on the Inclusion Criteria

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Manage episode 291158542 series 2818069
Content provided by The University of Texas Southwestern Medical Center - Adriane dela Cruz and Adriane dela Cruz. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The University of Texas Southwestern Medical Center - Adriane dela Cruz and Adriane dela Cruz or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

The article we discuss is MA Raskind et al. Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans. New England Journal of Medicine 2018; 378(6):507-517

For an example of an earlier study that DID find benefit of prazosin for PTSD, check out Raskind, MA et al. A Trial of Prazosin for Combat Trauma PTSD with Nightmares in Active-Duty Soldiers Returned from Iraq and Afghanistan. Am J Psychiatry 2013; 170: 1003-1010.

Recent meta-analyses of the efficacy of prazosin for PTSD can be found here and here.

A brief review on the ethical principles of equipoise in research.

  continue reading

11 episodes

Artwork
iconShare
 
Manage episode 291158542 series 2818069
Content provided by The University of Texas Southwestern Medical Center - Adriane dela Cruz and Adriane dela Cruz. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The University of Texas Southwestern Medical Center - Adriane dela Cruz and Adriane dela Cruz or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

The article we discuss is MA Raskind et al. Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans. New England Journal of Medicine 2018; 378(6):507-517

For an example of an earlier study that DID find benefit of prazosin for PTSD, check out Raskind, MA et al. A Trial of Prazosin for Combat Trauma PTSD with Nightmares in Active-Duty Soldiers Returned from Iraq and Afghanistan. Am J Psychiatry 2013; 170: 1003-1010.

Recent meta-analyses of the efficacy of prazosin for PTSD can be found here and here.

A brief review on the ethical principles of equipoise in research.

  continue reading

11 episodes

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