Best Haemochromatosis Podcasts (2024)

1
Iron, HFE haemochromatosis, and infections; bispecific antibodies improve CAR T-cell response; determinants of outcome in NPM1-mutated AML 23:31

1h ago23:31

23:31

In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro an…

1
Outcomes of younger patients with mantle cell lymphoma; M-protein assessment during maintenance therapy in multiple myeloma; in vivo CAR T-cell generation using lentiviral vectors 0:59

2h ago0:59

0:59

In this week's episode we’ll discuss the outcomes of younger patients with mantle cell lymphoma experiencing late relapse; learn more about mass spectrometry-based assessment of M-protein in peripheral blood during maintenance therapy in multiple myeloma and discuss in vivo CAR T-cell generation in non-human primates using lentiviral vectors. Featu…

1
Review Series on Factor XI 44:40

2h ago44:40

44:40

Introduced by Associate Editor Dr. Thomas Ortel, this bonus episode discusses the Review Series on Factor XI, published in volume 143 issue 15 of Blood Journal. Dr. Ortel is joined by contributing authors Owen McCarty, PhD, Gili Kenet, MD, and David Gailani, MD. Review Series Articles: Introduction to a review series on factor XI Biology of factor …

1
Episode 28: Dermatitis - A Humour’s Boiling Point 13:30

1h ago13:30

13:30

Dermatitis: What is it? How is it treated? What causes it? In this episode, we will explore the history, different types of dermatitis and eczema, and their symptoms. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources National Eczema Associatio…

1
Protective role of neonatal CMV infection in B-ALL; GVHD targets organoid-forming bile duct stem cells; seven-year outcomes for venetoclax-ibrutinib therapy in MCL 16:56

1h ago16:56

16:56

In this week's episode we'll learn how cytomegalovirus infection early in life depletes preleukemic cells in a mouse model of B-cell acute lymphoblastic leukemia. After that we'll discuss new research, where GVHD targets organoid-forming bile duct stem cells in a TGF-beta-dependent manner. Conversely, a TGF-beta inhibitor protects these stem cells …

1
Episode 27: Hirschsprung’s Disease - Where’s the Meconium? 10:46

6d ago10:46

10:46

Hirschsprung’s Disease: What is it? What are the risk factors? What are the symptoms? In this episode, we will delve into the history, diagnosis, and treatment of Hirschsprung’s disease. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources Reach …

1
Episode 26: Diabetes Mellitus - Sweet, Sweet Water 16:42

15d ago16:42

16:42

Diabetes Mellitus: What are the symptoms? What are the causes? And what is the difference between type 1 and type 2? In this episode, we will explore the history of diabetes, how it is tested, and how it is treated. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com…

1
Immune fitness and response to taclistamab in R/R multiple myeloma; BCR::ABL1 M244V mutation causes resistance to asciminib; HSCT and myocardial fibrosis in young patients with SCD 16:59

18d ago16:59

16:59

In this week's episode we’ll discuss how immune fitness impacts response to teclistamab in relapsed/refractory multiple myeloma; learn more about a new mechanism of resistance to asciminib conferred by the BCR::ABL1 M244V mutation, and discuss the impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell…

1
Episode 25: Polycystic Ovarian Syndrome - Pigeon Eggs or Almonds? 13:46

5d ago13:46

13:46

Polycystic Ovarian Syndrome: What is it, how is PCOS diagnosed, and what are its symptoms? In this episode, we will explore the history, current knowledge, and management of this condition. Tune in to learn more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources: PCOS …

1
Decitabine in older patients with AML; EPCR and sickle chronic kidney disease; lymphocyte depletion versus post-transplant cyclophosphamide for mismatched donor transplant for inborn errors of immunity ... 22:53

28d ago22:53

22:53

In this week's episode we’ll discuss the safety and efficacy of decitabine in older patients with AML; learn how heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice, and discuss the outcomes of treatment with HLA-mismatched HSCT with TCRab/CD19 lymphocyte depletion or post-HSCT cyclophosph…

1
Episode 24: Retinitis Pigmentosa - Morbus Arianus 12:45

12d ago12:45

12:45

Retinitis Pigmentosa: What causes it? Do we have a cure or treatment for it? What are the symptoms of it? In this episode, we will explore the causes, symptoms, and delve into the history of the condition. We will also discuss how it is diagnosed and take a brief look into blindness. Check out our website: https://anatomyofillness.com/ Molly Burke …

1
Impact of MRD-negative on PFS in myeloma; IPSS-R down-staging before transplant in MDS; hereditary angioedema and venous thromboembolism 21:50

19d ago21:50

21:50

In this week's episode we'll discuss minimal residual disease as an intermediate clinical endpoint for multiple myeloma. Then, we'll learn about IPSS-R downstaging before transplant in MDS. Finally we'll hear about the connection between hereditary angioedema and venous thromboembolism. Featured Articles: EVIDENCE meta-analysis: evaluating minimal …

1
Episode 23: Polycystic Kidney Disease - a 350 Year Mystery 10:18

21d ago10:18

10:18

Polycystic Kidney Disease: What do a Polish King and an American playwright have in common? What are the symptoms of PKD, and how do we treat it? In this episode, we delve into the history, symptoms, and causes of PKD. Tune in to find out more! Check out our website: https://anatomyofillness.com/ PKD Foundation (US): https://pkdcure.org/ PKD Charit…

1
Acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; alternative donor transplantation for severe aplastic anemia; clonal relapse dynamics in AML following allogeneic HCT 23:32

1M ago23:32

23:32

In this week's episode we’ll discuss the safety and efficacy of acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; learn more about alternative donor transplantation for severe aplastic anemia and discuss clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation. Featured Articles:…

1
Episode 22: Haemochromatosis - The Viking Disease 12:32

28d ago12:32

12:32

Haemochromatosis: What is it, what are the symptoms, and how is it treated? This episode will explore the history, cause, and treatment of Haemochromatosis. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Iron Disorders Institute (USA): https://irondisorders.org/about-idi/ Haemochromatosis UK: https://www.haemochromat…

1
Clinical impact of CRh in AML; thrombosis features in a real-life PNH cohort; and restriction of SOX11 expression to EBV-negative Burkitt lymphomas 19:58

1M ago19:58

19:58

In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants o…

1
Episode 21: Crohn's Disease and Ulcerative Colitis - Tuberculosis in my What? 13:51

1M ago13:51

13:51

Crohn’s disease and ulcerative colitis: What are they? What are the symptoms, and how do they differ? In this episode, we will explore the historical background, our current understanding of these conditions, and their treatments. Tune in to learn more. Check out our website: https://anatomyofillness.com/ Crohn’s and Colitis Foundation (US): https:…

1
Mutational and transcriptional landscape of pediatric BCP lymphoblastic lymphoma; the role of platelet-derived TGF-1 in immune thrombocytopenia; phase 3 trial of mavorixafor in WHIM syndrome 23:25

2M ago23:25

23:25

In this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome. Featured Articles: Mutational and transcriptional landscape of pedi…

1
Episode 20: Allergies and Anaphylaxis - What is Food to Some is Poison to Others 15:04

2M ago15:04

15:04

Allergies: What are they, what are the symptoms, and how do we treat them? In this episode, we delve into the causes of allergies, their history, and diagnosis methods. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Rubin_Allergy: https://www.instagram.com/rubin_allergy?igsh=eHhsaDhsempkZjh5 Movies featuring allergie…

1
GM-CSF coordinates shelter in the cytokine storm; Interleukin-1 as a therapeutic target in TTP; CAR T-cell outcomes across race and ethnicity in LBCL 19:57

2M ago19:57

19:57

In this week's episode we'll discuss new insights on the role of GM-CSF in establishing immune memory. The authors propose that the coordination of opposing immune memory programs, driven by GM-CSF, may be essential to efficient, yet controlled, innate immune responses. After that: Interleukin-1 inhibition in TTP. Researchers explore the potential …

1
Review Series on Oncogenic Signaling and Immune Evasion in Hematologic Malignancies 15:41

2M ago15:41

15:41

Introduced by Associate Editor Robert Zeiser, this Review Series focuses on the problem of immune escape by acute myeloid leukemia (AML). The series opens with a review of how AML escapes T-cell–driven elimination and then focuses on how p53 function impinges on AML recognition by immune cells. The series finishes with a summary of new approaches t…

1
Episode 19: Epilepsy - Not Caused by the Bad Spirits 25:38

2M ago25:38

25:38

Epilepsy: What is it, what are the symptoms, and how do we diagnose it? In this episode, we will delve into the cause of epilepsy, its history, and how we treat it. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Epilepsy Foundation (US): https://www.epilepsy.com/ Epilepsy Foundation (AUS): https://epilepsyfoundation.…

1
Reassessing the CLL prognostic index; ADAMTS13 conformation and risk of relapse in immune-mediated TTP; haploidentical bone marrow transplant in sickle cell disease 23:39

2M ago23:39

23:39

In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase …

1
Episode 18: Chronic Obstructive Pulmonary Disease - Not Just for Smokers 13:51

2M ago13:51

13:51

Chronic Obstructive Pulmonary Disease (COPD): What is it, what are the symptoms, and how do we treat it? In this episode, we discuss the two main conditions involved in COPD, who is at risk for it, and the history of the condition. Check out our website: https://anatomyofillness.com/ COPD Foundation (US): https://www.copdfoundation.org/ Asthma and …

1
A biomarker for disease severity in Wiskott-Aldrich Syndrome; loss of Dnmt3a confers resistance to IFNα; unrelated donor selection in HSCT with PTCy 19:16

2M ago19:16

19:16

In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell tran…

1
Episode 17: Duchenne Muscular Dystrophy - Calves that Aren’t from the Gym 15:03

2M ago15:03

15:03

Duchenne Muscular Dystrophy: What is it, what are the symptoms, and how do we treat it? This episode will cover the history, genetics, and testing for Duchenne Muscular Dystrophy. Check out our website: https://anatomyofillness.com/ Muscular Dystrophy Association: https://www.mda.org/ Duchenne UK: https://www.duchenneuk.org/ Duchenne Australia: htt…

1
Nilotinib with or without cytarabine for Philadelphia-positive AML; thrombosis risk in Factor V Leiden and Prothrombin G20210A; ctDNA improves prognostic prediction in relapsed/refractory multiple myeloma ... 23:05

2M ago23:05

23:05

In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in…

1
Episode 16: Graves’ Disease - The Thyroid, Not for Worms 18:32

2M ago18:32

18:32

Graves' Disease: What is it? What are the symptoms? In this episode, we will delve into the history of Graves' Disease, diagnosis methods, treatment options, and its underlying causes. Tune in to find out more. Check out our website: https://anatomyofillness.com/ British Thyroid Foundation: https://www.btf-thyroid.org/ Graves Disease And Thyroid Fo…

1
Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML 18:59

3M ago18:59

18:59

In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone…

1
Episode 15: Sickle Cell Anaemia - Not the Regular Anti-Malarial 17:59

3M ago17:59

17:59

Sickle cell anaemia: What is it? What are its symptoms and genetics? In this episode, we will explore the history, treatment, and the reasons behind the existence of this condition. The episode will also explain the potential complications associated with sickle cell anaemia. Tune in to find out more. Check out our website: https://anatomyofillness…

1
Effects of voxelotor on cerebral blood flow in pediatric sickle cell disease; thrombosis in Vexas syndrome; response to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia 22:26

3M ago22:26

22:26

In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia. Featured Articles: The influence of voxe…

1
Episode 14: Addison's Disease - Giving me an Adrenal Crisis 21:02

3M ago21:02

21:02

Addison's disease, what are the symptoms, and how do we test for it? In this episode, we go over the history that led to the discovery of Addison's disease, its causes, how we treat it, and some of the famous cases. A massive thanks to @leo_adrenal_insufficiency on Instagram for helping with this episode! Check out our website https://anatomyofilln…

1
Stamping out high-risk myeloma with D-KRd and tandem transplant; plasmin-cleaved VWF in microthrombosis; SCD plasma sensitizes iPSC-derived sensory neurons 19:40

3M ago19:40

19:40

In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. Featured Articles: Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem…

1
Episode 13: Breast Cancer - One in Eight 23:59

4M ago23:59

23:59

Breast cancer: What are the symptoms, and how common is it? This episode covers its history, risk factors, diagnostic tests, and much more. Check out our website: https://anatomyofillness.com/ Susan G Komen Foundation screening tools page: https://www.komen.org/breast-cancer/risk-factor/understanding-risks/gail-method/ American Breast Cancer Founda…

1
Allogeneic transplant in first remission for post-induction molecular MRD; circulating HSPCs actively participate in human hematopoiesis; let-7 miRNAs repress HIC2 to regulate BCL11A transcription and ... 21:44

3M ago21:44

21:44

In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcrip…

1
Episode 12: Achondroplasia - Not Caused by Wine Cults 11:09

4M ago11:09

11:09

Achondroplasia, what actually is it and how is it inherited? In this episode we go over achondroplasia throughout the times, including the belief of it being associated with an ancient wine cult, the genetics and diagnosis, as well as potential treatment options that are offered today. Check out our website: https://www.anatomyofillness.com/ If you…

1
ADAMTS13 recovery in caplacizumab-treated TTP; inhibition of venetoclax-resistant BCL2 variants with sonrotoclax; genomic insights from Castleman disease in twins 19:10

4M ago19:10

19:10

In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researche…

1
Episode 11: Scurvy - An Orange a Day Keeps the Scurvy Away 18:15

4M ago18:15

18:15

Scurvy, you hear its name and you think of pirates and old sea voyages. So why did pirates get scurvy? Is it an issue we still face today? If so how do we treat scurvy? To find out more about the history of scurvy and where we are with it today, tune into this week's episode! Check out our website: https://anatomyofillness.com/ References: https://…

1
Durable response after tisa-cel in adults with relapsed/refractory follicular lymphoma; high microRNA-145 plasma levels indicate decreased risk of VTE; epigenetic/immunogenetic signature in the prediction ... 23:49

4M ago23:49

23:49

In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and …

1
Episode 10: Coeliac disease - Not a Diet Trend 16:26

4M ago16:26

16:26

What is coeliac disease, and how long has it existed? In this episode we discuss the condition in the mouths of many talk show hosts and painted incorrectly in the show “Do Revenge”. Tune in to learn the truth behind this autoimmune condition, and why it is not just a trend. Check out our website: https://anatomyofillness.com/ If you're interested …

1
Gut microbiota exploitation by CPX-351 in AML; optimizing anti-myeloma immunity for ASCT; which pediatric ITP patients will develop lupus? 19:00

4M ago19:00

19:00

In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients wi…

1
Episode 9: Scoliosis - But have you tried Ladder Τherapy? 21:45

5M ago21:45

21:45

Scoliosis, what is it? An age old question that we have been trying to solve for centuries. Because of this, we have centuries of scoliosis medical devices, such as bracing or old exercise devices, with good intent but not always good results. Tune into this week's episode to find out about what we currently know about Scoliosis and how we currentl…

1
Jak2V617F clonal hematopoiesis promotes arterial thrombosis; Staphylococcus aureus infection in Sézary syndrome; clinical features of RAC2-related immunodeficiency 26:18

4M ago26:18

26:18

In this week's episode we’ll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency. Featured Articles: Jak2V617F clonal hemat…

1
Episode 8: Kawasaki disease - Not your normal Childhood Sniffles 17:48

5M ago17:48

17:48

Have you ever wondered what Kawasaki Disease is? What are the symptoms and why is it so dangerous? Tune in to this week's episode to find out about the history, symptoms and treatment of Kawasaki Disease as well as some interesting little tidbits. Check out our website: https://anatomyofillness.com/ If you're interested in Kawasaki Disease Foundati…

1
Molecular mimicry in aplastic anemia; emicizumab prophylaxis in infants with hemophilia; hydroxyurea reduces infections in SCA 19:54

4M ago19:54

19:54

In this week's episode we'll discuss molecular mimicry in aplastic anemia, novel experiments show that antigens associated with viral infections can mimic epitopes presented on hematopoietic progenitor cells. Then, we'll learn about prophylaxis with subcutaneous emicizumab in infants with hemophilia. Finally we'll see how hydroxyurea is associated …

1
Episode 7: Pheochromocytoma - You’re giving me an Adrenaline Rush 17:39

5M ago17:39

17:39

Pheochromocytoma, you may have heard this term thrown around in your favourite medical show, but how much do you know about it. What are the symptoms of pheochromocytoma, how do we diagnose it, how do we treat it, and how long have known about its existence? Which US president had it? Tune into this week's episode to find out. Check out our website…

1
Review Series on the Influence of the Tumor Microenvironment on the Pathogenesis of B-Cell Lymphomas 32:05

5M ago32:05

32:05

In this bonus episode of Blood Podcast, Associate Editor, Dr. Freda Stevenson is joined by Drs. Karin Tarte, Andrea Radtke, and Leandro Cerchietti to discuss the Review Series on the influence of the tumor microenvironment on the pathogenesis of B-cell lymphomas. Find the full review series in Blood Journal volume 143 issue 12.…

1
Free light chain mass spectrometry in diagnosis and monitoring of AL amyloidosis; T cells of AML patients in remission have distinct RNA signatures; and protective effect of ADAMTS13 in sickle cell mice ... 22:34

5M ago22:34

22:34

In this week's episode we’ll discuss the findings from a study assessing the utility of free light chain mass spectrometry in AL amyloidosis, learn more about distinct single-cell RNA-sequencing signatures of bone marrow T cells of AML patients in remission after an allogeneic stem cell transplant, and discuss why von Willebrand factor clearance is…

1
Episode 6: Preeclampsia/Eclampsia - Not a case of the Wandering Womb 21:36

5M ago21:36

21:36

Have you wondered what are the symptoms of preeclampsia? How long have we known about preeclampsia and how did we used to treat it? How do we treat it now, and what do we really know about it? Tune into this week's episode to find out. Check out our website: https://anatomyofillness.com/ Preeclampsia Foundation: https://www.preeclampsia.org/ Austra…

1
Eculizumab in transplant-associated thrombotic microangiopathy; reclassifying malignant monocytosis; targeting tissue factor in antiphospholipid syndrome 20:50

5M ago20:50

20:50

In this week's episode we'll discuss eculizumab in stem cell transplant-associated thrombotic microangiopathy. Then, we'll learn about reclassifying malignant monocytosis, these newly classified cases have distinct mutational and transcriptional profiles. Finally, we'll hear about targeting the tissue factor coagulation initiation complex prevents …

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