Best Matthew, and Ruben Podcasts (2024)

1
EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

11m ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

1
State Representatives Talk Criminal Legal System Reform in Wisconsin 44:15

6h ago44:15

44:15

Now former state representatives Evan Goyke and Dora Drake talk with Shannon about strategies, experiences, and hopes around criminal legal system reform in Wisconsin. Since this episode, both individuals have since moved on to different positions in government to continue this work.By The Community and MSOE

1
Ruba Abdelhadi - Enteral Nutrition and Feeding Tubes 101 54:09

2h ago54:09

54:09

In this episode, hosts Drs. Peter Lu and Jennifer Lee talk to Dr. Ruba Abdelhadi about enteral nutrition and feeding tubes. Dr. Abdelhadi is a pediatric gastroenterologist at Children's Mercy in Kansas City, MO where she is the Director of Nutrition Support Program. She is a Professor of Pediatrics at the University of Missouri-Kansas City School o…

1
EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

3d ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

1
EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

10d ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

1
Shannon talks agnostic/atheist formerly incarcerated success stories with Dominee & Matthew 1:06:52

11d ago1:06:52

1:06:52

Dominee Meek and Matthew Wick exchange stories with Shannon about all of their journeys through over 60 years in the system without believing in god: what they learned, how it limited their opportunities and path, and how it impacts their reentry journey.By The Community and MSOE

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Tanaz Danialifar - Carbs Causing Chaos: Disaccharidase Deficiencies 56:12

17d ago56:12

56:12

In this episode, hosts Drs. Peter Lu and Temara Hajjat talk to Dr. Tanaz Danialifar about diagnosing and treating disaccharidase deficiencies in children, including lactase deficiency and congenital sucrase-isomaltase deficiency (CSID). Dr. Danialifar is a pediatric gastroenterologist at Children's Hospital Los Angeles, where she is Associate Direc…

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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

17d ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

24d ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

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Ruben Gaona Talks Home Ownership & Entrepreneurship Post Incarceration 50:26

28d ago50:26

50:26

Shannon talks with Ruben Gaona about the pros and cons of entrepreneurship versus employment and rental versus homeownership for people with criminal records, particularly those still on “paper.” Ruben Gaona is the Executive Director of My Way Out, an organization focused on reentry support for formerly incarcerated individuals. Ruben's work has ea…

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Arun Singh - Clinical Conundrums in Celiac Disease 1:01:30

1M ago1:01:30

1:01:30

In this episode, hosts Drs. Temara Hajjat and Peter Lu talk to Dr. Arun Singh about some of the challenges we face when caring for children with celiac disease. Dr. Singh is Co-Director and Research Program Director of the Center for Celiac Disease at the Children's Hospital of Philadelphia and an Assistant Professor in the Perelman School of Medic…

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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

1M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

1
Simmone Kilgore Talks “Second Chance” Language and How to Carry Shame 38:58

1M ago38:58

38:58

Simmone Kilgore LPC, an experienced trauma therapist talks with Shannon about "Second Chance" language, shame, and her career. She knows incarceration closely in her family. Simmone is the ReCAST Program Manager within Milwaukee's Office of Violence Prevention and assists Milwaukee’s youth and families most vulnerable to systemic and community viol…

1
Maria Oliva-Hemker - Clostridioides Difficile Infection and Inflammatory Bowel Disease 1:07:43

1M ago1:07:43

1:07:43

In this episode, hosts Drs. Temara Hajjat and Peter Lu talk to Dr. Maria Oliva-Hemker about diagnosing and managing Clostridioides difficile (C. diff) in children who have inflammatory bowel disease (IBD). Dr. Oliva-Hemker is the Director of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition and the Stermer Family Professor for P…

1
EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

2M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

2M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

1
Kaleigh Atkinson & Shannon Talk Correcting the Narrative 39:31

2M ago39:31

39:31

Narrative work is foundational in not only the criminal legal system but in life overall. Kaleigh Atkinson and Shannon discuss the origins of the Correcting the Narrative campaign, how it has evolved over time, what they have learned, and where it is going next.By The Community

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Michael Narkewicz and Zachary Sellers - Liver Disease in Cystic Fibrosis 1:14:52

2M ago1:14:52

1:14:52

In this episode, hosts Drs. Jason Silverman and Temara Hajjat talk to Drs. Michael Narkewicz and Zachary Sellers about screening, evaluation and management of children with cystic fibrosis with hepatobiliary involvement and advanced CF liver disease. We review the new consensus recommendations paper published in the May issue of Hepatology (open ac…

1
EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

2M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

1
EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

2M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

1
Janos Marton Talks Reform & Abolition with Shannon 39:58

2M ago39:58

39:58

Janos Marton and I discuss the debate between reform and abolition around the criminal legal system. (Note: This episode was recorded 2 years ago.) Janos Marton is the Chief Advocacy Officer for Dream.Org, an organization committed to closing prison doors and opening doors of opportunity. Janos is a born and raised New Yorker who began his career a…

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Jason Silverman - Why Pediatric GI Needs Social Media (Special JPGN Episode) 1:02:02

2M ago1:02:02

1:02:02

In this episode, hosts Drs. Peter Lu and Temara Hajjat talk to Dr. Jason Silverman about how social media can be used in pediatric gastroenterology for patient care, research, medical education, and professional development. Dr. Silverman is an Associate Professor in the Division of Pediatric Gastroenterology and Nutrition at Stollery Children's Ho…

1
EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

2M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

1
EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

3M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

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Adam Procell and Shannon Ross go to Belize 1:03:18

3M ago1:03:18

1:03:18

What started out as an exploration of the possibilities of traveling while on paper (extended supervision) ultimately turned into a legitimate research project ending with Adam Procell and Shannon Ross traveling to the only non-profit prison in the world located in Belize.By The Community and MSOE

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Mike Wilsey - Esophageal Strictures in Children 1:00:28

3M ago1:00:28

1:00:28

In this episode, hosts Drs. Peter Lu and Jennifer Lee talk to Dr. Michael Wilsey about the evaluation and management of esophageal strictures in children, including congenital strictures and those arising from eosinophilic esophagitis and caustic ingestions. Dr. Wilsey is an advanced endoscopist at Johns Hopkins All Children's Hospital in St. Peter…

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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

3M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

3M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

1
Matthew Giefer and Brad Pasternak - Tackling Prior Authorizations and Medication Approval 58:24

3M ago58:24

58:24

In this episode, Temara Hajjat and Jenn Lee interview Dr. Matthew Giefer and Dr. Brad Pasternak. Drs. Giefer and Pasternak share their experience advocating for the approval of medications for their patients. The discussion also covers the challenges involved in medication approval, how to approach your local and state representatives, and lobbying…

1
EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

3M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

4M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

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Ruben Quiros-Tejeira - Multivisceral Transplantation 1:08:42

4M ago1:08:42

1:08:42

In this episode, hosts Drs. Temara Hajjat and Jason Silverman talk to Dr. Ruben Quiros-Tejeira about multivisceral transplantation in children, covering indications, complications and the importance of multidisciplinary team care in this population. Dr. Quiros-Tejeira is Chief of the Division of Gastroenterology, Hepatology and Nutrition, a Profess…

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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

4M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

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EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

4M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

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Samuel Nurko - Using Neuromodulator Medications for Functional Abdominal Pain 59:45

4M ago59:45

59:45

In this episode, hosts Drs. Peter Lu and Jason Silverman talk to Dr. Samuel Nurko about using neuromodulator medications like tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) for children with functional abdominal pain disorders, now known as pain-predominant disorders of gut-brain interaction (DGBIs). We discuss the ra…

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EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

4M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

1
EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

5M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

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Praveen Goday - The Picky Eater 59:08

5M ago59:08

59:08

In this episode, hosts Drs. Peter Lu and Jennifer Lee talk to Dr. Praveen Goday about evaluating and treating the child who is a picky eater or who has developed a pediatric feeding disorder. Dr. Goday is Professor of Pediatrics at The Ohio State University College of Medicine and Director of the Nutrition and Feeding Programs at Nationwide Childre…

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EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

5M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

1
Romania presentation 9:08

5M ago9:08

9:08

By 17-21 EuroKids 24 News E+

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EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

5M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

1
Neha Santucci - Functional Abdominal Pain in "Organic" GI Diseases 58:24

5M ago58:24

58:24

In the this episode, hosts Drs. Temara Hajjat and Peter Lu talk to Dr. Neha Santucci, an Associate Professor of Pediatrics and the Director of the Disorders of Gut-Brain Interaction Program at Cincinnati Children's. They discuss how to identify and manage functional abdominal pain in children with pre-existing organic GI disorders. Learning Objecti…

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EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

5M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

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EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

5M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

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6B Ruben - Mary, Leo, Sophie and Isra interviewing Joaquin, our English teacher 16:15

6M ago16:15

16:15

By 17-21 EuroKids 24 News E+

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Lisa McMahon and Michael Rosen - Surgery in Ulcerative Colitis 1:05:33

6M ago1:05:33

1:05:33

In the this episode, hosts Drs. Temara Hajjat and Jenn Lee talk to Dr. Lisa McMahon, Chair of Surgery at Phoenix Children's, and Dr. Michael Rosen, Director of the Stanford Medicine Children's Health Center for IBD and Celiac Disease. They discuss managing and counseling a pediatric patient with ulcerative colitis and their family who may need cole…

1
EP 119: Revolutionising drug discovery: how the Pharma Proteomics Project is combining genetic and proteomic data with Chris Whelan 38:25

6M ago38:25

38:25

0:00 Introduction 01:00 Chris’ background and career to date 02:10 What is the Enigma Project? 04:48 How is genetics being applied to drug discovery today and how does proteomics fit in? 09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up 10:57 54k UK Biobank participants tested - discussion of findings 14:33 The…

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EP 118: The role of genetics in drug discovery and development with Dr. Matt Nelson 42:56

6M ago42:56

42:56

Summary: 0:00 Introduction 5:45 Lessons learned from 15 years at GSK: How has genetics and drug discovery evolved over time? 8:10 Matt’s seminal 2015 paper: Quantifying the impact of human genetic evidence on the probability of success in drug development 11:40 Which types of genetic evidence are the best drivers of success in clinical trials? 13:3…

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Bill Balistreri - Hepatology Year in Review 57:55

6M ago57:55

57:55

In the first episode of 2024, hosts Drs. Temara Hajjat and Jason Silverman talk to Dr. William Balistreri about some of the new developments in the hepatology field over the past year. This episode is eligible for CME credit! Once you have listened to the episode, click this link to claim your credit. Credit is available to NASPGHAN members (if you…

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EP 117: Wendy Chung: whole genome newborn screening and other big opportunities in genomic medicine. 47:51

6M ago47:51

47:51

Summary: 0:00 Introduction 1:45 Wendy’s early career looking into the genetics of diabetes through mouse models 6:23 A high altitude view: Cutting through hype to spot the next wave of game-changing technology 8:03 The role of policy and communication: how Wendy’s work goes beyond the lab to create real-world impact 11:20 Wendy’s choice to do an MD…

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Matthew, And Ruben Podcasts

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