Best Tucker Goodrich Podcasts (2024)

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Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich | IS #1 20:38

17d ago20:38

20:38

Send us a Text Message. About the guest: Tucker Goodrich is an independent researcher and self-described “seed oil zealot” who credits many of his own health improvements with minimizing his consumption of industrial seed oils. He runs a Substack page, and provides interesting commentary about scientific research on seed oils, metabolic health, and…

1
History of Diet & Food, Population Density & Social Stability, Psychological Pandemics, Physical & Mental Health in Civilizational Cycles | Rudyard Lynch | IS #2 36:23

1h ago36:23

36:23

Send us a Text Message. About the guest: Rudyard Lynch is a history and anthropology scholar and host of the popular YouTube channel, whatifalthist. Episode summary: Nick and Rudyard discuss: history of agriculture, diet & food; population density, social structure, and social behavior; the rise and fall of civilizations; history and future of reli…

1
Evolution: Natural Selection, Genetic Drift, Origin of Life, Cellular Complexity, Epigenetics | Michael Lynch | #166 1:29:28

27m ago1:29:28

1:29:28

Send us a Text Message. About the guest: Michael Lynch, PhD is an evolutionary biologist at Arizona State University who studies the origins of genomic and cellular complexity. Episode summary: Nick and Dr. Lynch discuss: natural selection vs. genetic drift; genetic mutations & the speed of evolution; origin of life; the evolution of cellular compl…

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PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet | #165 1:41:18

3d ago1:41:18

1:41:18

Send us a Text Message. About the guest: Richard Bazinet, PhD is neurochemist and nutritional scientist at the University of Toronto. His lab studies brain lipid metabolism in health and disease. Episode summary: Nick and Dr. Bazinet discuss: lipid metabolism in the liver and brain; dietary fatty acids (saturated, monounsaturated, polyunsaturated);…

1
Dopamine, Reward, Motivation, Lateral Hypothalamus, Feeding Behavior & Eating Disorders | Melissa Sharpe | M&M #164 1:08:39

19d ago1:08:39

1:08:39

Send us a Text Message. About the guest: Melissa Sharpe, PhD is a neuroscientist. Her lab at the University of Sydney studies reinforcement and reward learning in rodents. Episode summary: Nick and Dr. Sharpe discuss: dopamine and its association with reward learning and motivation; reinforcement learning & the brain; the lateral hypothalamus and f…

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Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | M&M #163 1:44:35

22d ago1:44:35

1:44:35

Send us a Text Message. About the guest: Boris Heifets, MD, PhD is an anesthesiologist and researcher at Stanford University. His lab studies non-ordinary states of consciousness and psychoactive drugs like MDMA, ketamine, and psychedelics. Episode summary: Nick and Dr. Heifets discuss: anesthesia and how anesthetics work; placebo effects & expecta…

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Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine, Marijuana & Alcohol | Robert Malenka | #162 1:34:42

28d ago1:34:42

1:34:42

Send us a Text Message. About the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior. Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plastici…

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GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | #161 1:32:36

1M ago1:32:36

1:32:36

Send us a Text Message. About the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic d…

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Diet, Hunting, Culture and Evolution of Paleolithic Humans & Hunter Gatherers | Eugene Morin | M&M #160 1:24:10

2M ago1:24:10

1:24:10

Send us a Text Message. About the guest: Eugene Morin, PhD is a Professor of Anthropology at the University of Trent who studies Paleolithic humans and animals. Episode summary: Nick and Dr. Morin discuss evolution of Paleolithic humans; Neanderthal diet & cultural capacity; key human adaptations related to endurance and stamina; hunter gatherer hu…

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Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | M&M #159 1:26:45

2M ago1:26:45

1:26:45

Send us a Text Message. About the guest: Monique Smith, PhD is an assistant professor of neurobiology at the University of California-San Diego, where her lab studies the neuroscience of social behavior, pain, and emotion. Episode summary: Nick and Dr. Smith discuss: the neurobiology of pain perception; social & empathy-like behavior in animals; em…

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Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman 1:13:26

2M ago1:13:26

1:13:26

Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time. He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: …

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Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino | #158 1:41:30

2M ago1:41:30

1:41:30

Send us a Text Message. About the guest: Dominic D'Agostino, PhD is a researcher and professor at the University of South Florida, where his lab studies metabolism, human biology, and related subjects. Episode summary: Nick and Dr. D'Agostino discuss: ketosis and the ketogenic diet; effects of ketosis on diabetes, insulin resistance & metabolic hea…

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Preventative Medicine, Diet & Lifestyle vs. Pharmaceuticals in Health & Disease, Lies Taught in Medical Schools | Robert Lufkin | #157 1:45:15

2M ago1:45:15

1:45:15

Send us a Text Message. About the guest: Robert Lufkin, MD is a radiologist and professor at UCLA. His new book is called, "Lies I Taught in Medical School." Episode summary: Nick and Dr. Lufkin talk about: the history of medicine in the United States; diet & lifestyle vs. pharmaceuticals in acute vs. chronic disease; diabetes, metabolic syndrome &…

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Ep. 22: John Speakman—What Causes Obesity? 1:33:56

2M ago1:33:56

1:33:56

Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total D…

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Psychology of Stress, Resilience, Emotion & Child Development | Stephen Sideroff | #156 1:39:59

2M ago1:39:59

1:39:59

Send us a Text Message. About the guest: Stephen Sideroff, PhD is a clinical psychologist and Associate Professor of Psychiatry and Behavioral Sciences at UCLA. His new book is, "The 9 Pillars of Resilience." Episode summary: Nick and Dr. Sideroff discuss: childhood & developmental psychology; clinical & Gestalt psychology; stress & resilience; pha…

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Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley 1:21:29

2M ago1:21:29

1:21:29

Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our…

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Cell Biology of Aging, Mitochondria, Metabolism, Autophagy & Stress | Andrew Dillin | #155 1:39:45

3M ago1:39:45

1:39:45

Send us a Text Message. About the guest: Andrew Dillin, PhD is Professoer of Molecular & Cell Biology at UC-Berkeley and Howard Hughes Medical Institute investigator. His lab studies mechanisms of aging, mitochondrial biology, and related subjects. Episode summary: Nick and Dr. Dillin discuss: cell biology; mitochondria & the endoplasmic reticulum;…

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Evolution & Genetics of Human Diet, Metabolism, Disease Risk, Skin Color & Origins of Modern Europeans | Eske Willerslev | #154 1:52:23

3M ago1:52:23

1:52:23

Send us a Text Message. About the guest: Eske Willerslev, PhD is an evolutionary biologist and Professor of evolution at both the University of Copenhagen and University of Cambridge. Episode summary: Nick and Dr. Willerslev discuss: human evolution out of Africa; the origins of modern Europeans; hunter gatherers, early farmers, and pastoralists; g…

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Diet, Nutrition, Metabolic Psychiatry, Brain & Mental Health | Georgia Ede | #153 1:51:27

3M ago1:51:27

1:51:27

Send us a Text Message. About the guest: Georgia Ede, MD is a psychiatrist and author of, "Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, And Protect Memory for a Lifetime of Optimal Mental Health." Episode summary: Nick and Dr. Ede discuss: glucose vs. ketones for brain energy; metabolic health & insulin res…

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Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt) 43:09

3M ago43:09

43:09

By Tucker D. Goodrich

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Plant Chemistry, Cannabinoids, Cannabis Terpenes & the Entourage Effect | Ryan Vandrey | #152 1:30:43

3M ago1:30:43

1:30:43

Send us a Text Message. About the guest: Ryan Vandrey, PhD is a Professor of Psychiatry & Behavioral Sciences at Johns Hopkins University, where his lab studies the behavioral pharmacology of cannabis (marijuana), nicotine/tobacco, and other substances. Episode summary: Nick and Dr. Vandrey discuss: marijuana; cannabinoids like THC; terpenes like l…

1
Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)? 2:31:32

3M ago2:31:32

2:31:32

Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish…

1
Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151 2:28:31

3M ago2:28:31

2:28:31

Send us a Text Message. About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. His research focuses on the biology of aging and longevity. Episode summary: Nick and Dr. Kaeberlein discuss: the biology of aging; mTOR, FGF1, growth & metabolism; sirtuins, NAD & NMN; longevity drugs like metformin …

1
Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley 45:40

3M ago45:40

45:40

Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of wh…

1
Anorexia Remission Using Keto? - Valerie Anne Smith 1:48:22

3M ago1:48:22

1:48:22

Valerie Anne Smith had treatment-resistant anorexia for decades. Nothing seemed to work. Then, she achieved remission using an animal-based keto diet, along with two other people in a case series conducted by previous podcast guest Dr. Nick Norwitz. N.B. This podcast is not medical advice. It is presented for purely informational purposes only. Alt…

1
Visual System, Visual Impairments & Cures, Amblyopia, Neuroplasticity, Critical Periods & Metaplasticity, Ketamine & Psychedelics | Mark Bear | #150 1:16:10

3M ago1:16:10

1:16:10

Send us a Text Message. About the guest: Mark Bear, PhD is a Professor of Neuroscience at MIT, where his lab studies the visual system, neuroplasticity, and the pathophysiology of amblyopia and visual impairments. Episode summary: Nick and Dr. Bear discuss: the visual system in the brain, from the retina to visual cortex; critical periods of brain …

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DNA & RNA Biology, mRNA Vaccines, Vaccine Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan | #149 1:50:48

4M ago1:50:48

1:50:48

Send us a Text Message. About the guest: Kevin McKernan is the Chief Science Officer at Medicinal genomics and has been working the the biotechnology sector and conducting genomics research going back to his involvement in the Human Genome Project. Episode summary: Nick and Kevin discuss: basics of DNA and RNA biology; mRNA vaccines and how they wo…

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Ep. 17: Making Better Meat—Autumn Smith and John Etchart 1:16:45

4M ago1:16:45

1:16:45

Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize …

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Dietary Protein, Muscle Growth, Resistance Training, Amino Acids, Plant vs. Animal Protein Sources, Anabolic Growth | Luc van Loon | #148 1:22:33

4M ago1:22:33

1:22:33

Send us a Text Message. About the guest: Luc van Loon, PhD is a Professor of Physiology of Exercise and Nutrition and Head of the M3-research group at the Department of Human Biology at Maastricht University. His lab focuses on the skeletal muscle adaptive response to physical (in)activity, the impact of nutrition on metabolism, and related topics.…

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Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni | #147 1:21:08

4M ago1:21:08

1:21:08

Send us a Text Message. About the guest: Tommaso Di Ianni, PhD is an Assistant Professor in the Departments of Psychiatry & Behavioral Sciences and Radiology & Biomedical Imaging at the University of California, San Francisco. His lab uses ultrasound technology and deep learning to study the brain. Episode summary: Nick and Dr. Di Ianni discuss: th…

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Photobiology, Sunlight, Firelight, Incandescent Bulbs vs. LEDs, Mitochondria, Melatonin, Sunscreen & the Optics of the Body | Scott Zimmerman | #146 1:17:28

4M ago1:17:28

1:17:28

Send us a Text Message. About the guest: Scott Zimmerman is an optical engineer and photobiology expert Episode summary: Nick and Scott talk about: how light interacts with the body and affects our cells; melatonin as an antioxidant; how red & near-infrared light affect mitochondria; sunlight, fire light, and artificial light; incandescent light bu…

1
Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of Acquired Characteristics | Bruce Blumberg | #145 1:31:17

4M ago1:31:17

1:31:17

Send us a Text Message. About the Guest: Bruce Blumberg, PhD is a Professor of Cell & Developmental Biology at UC-Irvine. HIs lab studies epigenetics, gene x environment interactions, hormones & endocrine disruptors, obesogens & environmental toxins, and more. Episode Summary: Nick and Dr. Blumberg discuss: Embryonic development; hormones and hormo…

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Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley 1:28:20

4M ago1:28:20

1:28:20

Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) proces…

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Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant | #144 1:32:14

4M ago1:32:14

1:32:14

Send us a Text Message. About the Guest: Clare Bryant, DVM is a Professor of Innate Immunity at Cambridge University. Her lab studies the innate immune system, pathogen detection, inflammation, and chronic disease. Episode Summary: Nick and Dr. Bryant discuss: mechanisms of inflammation; inflammasomes & fatty acids; infection & disease; innate vs. …

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Gut-Brain Communication, Vagus Nerve, Fats & Sugars, Food Addiction, Gut Hormones & Weight Loss Drugs | Will de Lartigue | M&M #143 1:27:25

4M ago1:27:25

1:27:25

Send us a Text Message. Dr. Guillaume (Will) de Lartigue is a neuroscientist at the Monell Chemical Senses Center. His lab studies the neurobiology of eating, including how the vagus nerve senses internal stimuli in the gut. They discuss: gut-brain communication; the vagus nerve; gut hormones like leptin & GLP-1; weight loss drugs like Ozempic; glu…

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Endogenous DMT in the Mammalian Brain | Nicolas Glynos | #142 1:36:44

5M ago1:36:44

1:36:44

Send us a Text Message. Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal glan…

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Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon | #141 2:14:18

5M ago2:14:18

2:14:18

Send us a Text Message. About the Guest: Terrence Deacon, PhD is a Professor in the department of Anthropology at UC-Berkeley. He has written many papers and multiple books about the evolution of human language, origins of consciousness, and related topics. Episode Summary: Nick and Dr. Deacon discuss various aspects of biological evolution, from n…

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Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley 1:58:50

5M ago1:58:50

1:58:50

Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and t…

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Dr. Anthony Chaffee - The Plant Free MD 1:05:26

5M ago1:05:26

1:05:26

Dr Anthony Chaffee is an American medical doctor and neurosurgical resident who, over a span of 20+ years, has researched the optimal nutrition for human performance and health. It is his assertion that most of the so-called chronic diseases we treat as doctors are caused by the food we eat, or don't eat, and can be reversed with dietary changes to…

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Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | #140 1:59:34

5M ago1:59:34

1:59:34

Send us a Text Message. About the guest: Robert Lustig, MD is a physician-researcher and expert of metabolic health. He is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF), specializing in neuroendocrinology with an emphasis on the regulation of energy balance by the central nervous s…

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Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson | #139 1:41:19

5M ago1:41:19

1:41:19

Send us a Text Message. About the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution." Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative …

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Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley 56:57

5M ago56:57

56:57

Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who hav…

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Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | #138 1:53:19

5M ago1:53:19

1:53:19

Send us a Text Message. Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutiona…

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DMT, Serotonin, Inflammation, Psychedelics, and Past, Present & Future of Psychedelic Medicine | David & Charles Nichols | M&M #137 1:37:36

5M ago1:37:36

1:37:36

Send us a Text Message. Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketam…

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Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley 1:31:05

6M ago1:31:05

1:31:05

Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his…

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Ep. 12: Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn 40:32

6M ago40:32

40:32

Introduction We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural ep…

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Seed Oils, Omega-6 Fats, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | #136 1:33:49

6M ago1:33:49

1:33:49

Send us a Text Message. Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic…

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Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham 1:31:34

6M ago1:31:34

1:31:34

We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impa…

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History of Diet Trends & Medical Advice in the US, Fat & Cholesterol, Seed Oils, Processed Food, Ketogenic Diet, Can We Trust Public Health Institutions? | Orrin Devinsky | #135 1:41:12

6M ago1:41:12

1:41:12

Send us a Text Message. Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity…

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Omega-6-9 Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | #134 1:27:29

6M ago1:27:29

1:27:29

Send us a Text Message. Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable &…

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