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982-Trauma Related Brain Damage: Neurotoxicity of Stress
Manage episode 425561725 series 2325449
### Video Summary
**Title:** Trauma Related Brain Damage, Glutamate, and Neurotoxicity
**Presenter:** Dr. Dawn-Elise Snipes
**Link:** [Watch the video](https://youtu.be/AFsqzW8DBYc?si=Asi1zJlYqabK-Vn6)
---
#### Introduction
- Overview of trauma's effect on brain glutamate levels
- Discusses impact on HPA axis and neurotransmitter balance
- Importance of glutamate in learning and synaptic plasticity
#### Effects of Glutamate Imbalance
- Role of glutamate and cortisol in brain function
- Goldilocks principle: need for balanced neurotransmitter levels
- Symptoms of too little and too much glutamate
- Too little: difficulty concentrating, fatigue, apathy
- Too much: excitotoxicity, anxiety, neurodegeneration
#### Glutamate and Dopamine Interactions
- Dopamine potentiates glutamate, increasing neurotoxicity
- Impact of stimulants on glutamate release
#### HPA Axis and Stress Response
- Explanation of HPA axis function and stress response
- Chronic stress leads to pathophysiological changes and neuronal death
- Hypervigilance and its effects on cortisol and glutamate levels
#### Impact of Trauma and PTSD
- Trauma disrupts sense of safety, causing hypervigilance
- Persistent hypervigilance leads to chronic high glutamate and cortisol
- Stress-induced changes in prefrontal cortex and hippocampus affecting cognitive functions
#### Neurotransmission Dysfunction
- Glutamatergic dysfunction linked to stress-related mental and physical illnesses
- Systemic inflammation associated with depression, anxiety, autoimmune diseases
#### Interventions and Recovery
- Glutamate antagonists and their effects
- Importance of nutrients in normalizing glutamate levels
- Role of adaptogens, neuro lipids, and essential oils
- Behavioral strategies: creating safety, addressing intrusive thoughts, and flashbacks
- Cognitive and acceptance-based therapies for trauma
- Benefits of meditation and exercise in neurogenesis and stress reduction
#### Summary
- Glutamate is crucial for brain function but must be balanced
- Chronic stress impacts glutamate regulation, leading to various health issues
- Multiple interventions can help in managing glutamate levels and improving overall brain health
---
### Time Codes for Major Points
02:00 Overview of glutamate's role in the brain and effects of imbalance
07:45 Interaction between dopamine and glutamate, and impact of stimulants
13:30 Explanation of the HPA axis and its role in stress response
20:15 Impact of trauma and PTSD on glutamate and cortisol levels
25:50 Neurotransmission dysfunction and its link to mental and physical illnesses
35:30 Interventions for managing glutamate levels and improving brain health
Learn more about your ad choices. Visit megaphone.fm/adchoices
964 episodes
Manage episode 425561725 series 2325449
### Video Summary
**Title:** Trauma Related Brain Damage, Glutamate, and Neurotoxicity
**Presenter:** Dr. Dawn-Elise Snipes
**Link:** [Watch the video](https://youtu.be/AFsqzW8DBYc?si=Asi1zJlYqabK-Vn6)
---
#### Introduction
- Overview of trauma's effect on brain glutamate levels
- Discusses impact on HPA axis and neurotransmitter balance
- Importance of glutamate in learning and synaptic plasticity
#### Effects of Glutamate Imbalance
- Role of glutamate and cortisol in brain function
- Goldilocks principle: need for balanced neurotransmitter levels
- Symptoms of too little and too much glutamate
- Too little: difficulty concentrating, fatigue, apathy
- Too much: excitotoxicity, anxiety, neurodegeneration
#### Glutamate and Dopamine Interactions
- Dopamine potentiates glutamate, increasing neurotoxicity
- Impact of stimulants on glutamate release
#### HPA Axis and Stress Response
- Explanation of HPA axis function and stress response
- Chronic stress leads to pathophysiological changes and neuronal death
- Hypervigilance and its effects on cortisol and glutamate levels
#### Impact of Trauma and PTSD
- Trauma disrupts sense of safety, causing hypervigilance
- Persistent hypervigilance leads to chronic high glutamate and cortisol
- Stress-induced changes in prefrontal cortex and hippocampus affecting cognitive functions
#### Neurotransmission Dysfunction
- Glutamatergic dysfunction linked to stress-related mental and physical illnesses
- Systemic inflammation associated with depression, anxiety, autoimmune diseases
#### Interventions and Recovery
- Glutamate antagonists and their effects
- Importance of nutrients in normalizing glutamate levels
- Role of adaptogens, neuro lipids, and essential oils
- Behavioral strategies: creating safety, addressing intrusive thoughts, and flashbacks
- Cognitive and acceptance-based therapies for trauma
- Benefits of meditation and exercise in neurogenesis and stress reduction
#### Summary
- Glutamate is crucial for brain function but must be balanced
- Chronic stress impacts glutamate regulation, leading to various health issues
- Multiple interventions can help in managing glutamate levels and improving overall brain health
---
### Time Codes for Major Points
02:00 Overview of glutamate's role in the brain and effects of imbalance
07:45 Interaction between dopamine and glutamate, and impact of stimulants
13:30 Explanation of the HPA axis and its role in stress response
20:15 Impact of trauma and PTSD on glutamate and cortisol levels
25:50 Neurotransmission dysfunction and its link to mental and physical illnesses
35:30 Interventions for managing glutamate levels and improving brain health
Learn more about your ad choices. Visit megaphone.fm/adchoices
964 episodes
All episodes
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