The Skinny on Skin – John M. Newsam, Author, and CEO of Tioga Research – Research and Development of Formulations for the Skin

Finding Genius Podcast

John M. Newsam, author, and CEO of Tioga Research, discusses skin in general, care for skin, and his work at Tioga Research.

Podcast Points:

• An overview of transdermal drug delivery
• Active versus inactive ingredients
• Do enzymes break down proteins? — a focus on skin and products for the skin

Newsam has provided his expertise in scientific and strategic consulting to multiple US Fortune500 companies, as well as early-phase biotech and materials companies around the globe, including the US, UK, and Korea. He has worked with notable government institutions such as IFP Energies Nouvelles, and he has been a respected member of many academic advisory committees.

Newsam provides an overview of Tioga Research, their objectives in research, and overall mission. As he states, they are heavily involved in research and early development of formulations applied to the skin, including pharmaceutical (primary) as well as the beauty/skin care area as well. Newsam explains how ‘active’ ingredients are diffused into the skin in order to achieve the desired therapeutic benefit, and he talks about transdermal delivery of drugs, and why this method can be particularly useful.

The research CEO provides an overview of active and inactive ingredients, and FDA-approved products. As he states, cocktails of molecules tend to work best for delivering the benefits to users. Newsam explains how they have worked to assemble a long list of safe compounds and mixtures, and databases of useful excipients (inactive substances). Continuing, Newsam delivers an overview of what manufacturers can claim regarding their products and the benefits they may provide. As he states, in theory, any claim of benefit should be supported by a scientific study, but the cosmetic industry is so large, with so many products on the market, it can be difficult to police every product that exists.

Additionally, Newsam talks about other drugs, permeability, and how enzymes can degrade proteins. Newsam is a materials chemist by training, and he has authored in excess of 170 scientific publications.

Visit these links to find out more about John M. Newsam:

https://www.linkedin.com/in/jnewsam/

https://www.researchgate.net/profile/John_Newsam

https://scholar.google.com/citations?user=1fk9pdIAAAAJ&hl=en

https://profiles.ucsd.edu/john.newsam

https://en.wikipedia.org/wiki/John_M._Newsam