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Laboraverum News, 2024-06-12: New findings about why autism is so much more common in men than women
Manage episode 423198181 series 3550131
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We don't know why mental disorders such as schizophrenia, bipolar disorder or autism spectrum disorder are so much more common in men than in women, but new research suggests this may be due to significantly greater variability in the way RNA is synthesised on genes in women's brains. The researchers analysed 2,160 brain samples from patients with schizophrenia, bipolar disorder or autism spectrum disorder. Female patient samples showed more variation in the intensity of RNA synthesis on some parts of DNA, which is scientifically described as a “higher burden of transcriptomic dysfunction”. As a result, RNA written from genes such as SCN2A, FGF14 and C3 are much more represented in women's brains compared to men’s brains. The interesting thing here is that we are not talking about the presence or absence of genes that cause diseases or, conversely, fight them, and not even about the activity of DNA reading as such, but about a variability as a key factor.
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