Best Harold Nicoll Podcasts (2024)

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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

1d ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

8d ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

15d ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

22d ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

29d ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

1M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

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EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

1M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

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EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

2M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

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EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

2M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

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Benefits of Weight Lifting 19:09

2M ago19:09

19:09

Renowned fitness expert and author Beth Linder-Moss emphasizes the universal benefits of weightlifting in her latest episode of the Beth Linder-Moss Podcast, with her co-host Harold Nicoll. The conversation, which spanned from the significance of resistance training across various sports to the impact of weightlifting on older adults, underscores a…

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EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

2M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

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EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

2M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

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EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

3M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

1
Meditation and Fitness 12:09

3M ago12:09

12:09

On this edition of the Beth Linder-Moss Podcast, Beth explores how meditation positively impacts physical fitness. Research suggests that combining the two can: Improve physical performance Help achieve fitness goals Reduce illnesses Increase mind-body awareness Encourage healthy aging Improve focus and concentration Foster a stronger mind-muscle c…

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EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

3M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

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EP 119: Revolutionising drug discovery: how the Pharma Proteomics Project is combining genetic and proteomic data with Chris Whelan 38:25

3M ago38:25

38:25

0:00 Introduction 01:00 Chris’ background and career to date 02:10 What is the Enigma Project? 04:48 How is genetics being applied to drug discovery today and how does proteomics fit in? 09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up 10:57 54k UK Biobank participants tested - discussion of findings 14:33 The…

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Vegan and Vegetarian Diet Benefits 19:03

3M ago19:03

19:03

While vegetarianism and veganism are not new, misconceptions about what each entail and the differences between them are not well understood. On her popular podcast, Beth Linder-Moss clarifies common misconceptions about plant-based diets. She emphasizes that vegan diets exclude all animal products like dairy and eggs, as opposed to vegetarian diet…

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EP 118: The role of genetics in drug discovery and development with Dr. Matt Nelson 42:56

3M ago42:56

42:56

Summary: 0:00 Introduction 5:45 Lessons learned from 15 years at GSK: How has genetics and drug discovery evolved over time? 8:10 Matt’s seminal 2015 paper: Quantifying the impact of human genetic evidence on the probability of success in drug development 11:40 Which types of genetic evidence are the best drivers of success in clinical trials? 13:3…

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Working Out When Away from Home 17:02

3M ago17:02

17:02

This week on the Beth Linder-Moss Podcast fitness tips for frequent travelers. If you've ever found yourself searching for a gym while lugging a suitcase, you're in the right place. Fitting in a workout can be nothing short of a Herculean effort. There are those fortunate times when a gym is just a hop, skip, and a jump away from your lodging, but …

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EP 117: Wendy Chung: whole genome newborn screening and other big opportunities in genomic medicine. 47:51

4M ago47:51

47:51

Summary: 0:00 Introduction 1:45 Wendy’s early career looking into the genetics of diabetes through mouse models 6:23 A high altitude view: Cutting through hype to spot the next wave of game-changing technology 8:03 The role of policy and communication: how Wendy’s work goes beyond the lab to create real-world impact 11:20 Wendy’s choice to do an MD…

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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick 52:34

4M ago52:34

52:34

0:00 Introduction 4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study 8:30 Linking clonal hematopoiesis to cancer and cardiovascular health 11:22 Interplay of germline and somatic variants in clonal expansion 17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk 19:00 How clon…

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EP 115: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 2) 1:35:11

4M ago1:35:11

1:35:11

In the second instalment of our annual round-up episode, we welcome back Dr. Veera Rajagopal to cover the biggest stories in genetics and precision medicine of the last 12 months. Don’t forget to give the first instalment of our 2023 round-up a listen. Veera is a scientist at Regeneron with an interest in human genetics and drug target discovery in…

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EP 114: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 1) 1:10:35

4M ago1:10:35

1:10:35

0:00 Introduction 1:30 Veera’s personal highlights of 2023 Publication in Nature Genetics: Rare coding variants in CHRNB2 reduce the likelihood of smoking, an exome-wide association study identifying rare coding variants in CHRNB2 that may reduce the likelihood of smoking. Designing cover art Genetic links to neural circuits and their role in addic…

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EP 113: Harnessing human genetics to discover co-evolved small molecule medicines with Dr. Jason Park, CEO of Empress Therapeutics 44:31

5M ago44:31

44:31

In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines. Summary: 0:00 Intro 1:20…

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EP 112: Making the leap: the scientists collaborating to transform genetic targets into next generation treatments, with David Ochoa 41:36

5M ago41:36

41:36

This week on The Genetics Podcast Patrick is joined by David Ochoa, Platform Coordinator at Open Targets. They discuss how the Open Targets platform is enabling game-changing collaboration between academic research and big pharma. Working with partners including Sanofi, GlaxoSmithKline, Bristol Myers Squibb, Genentech and Pfizer, Open Targets power…

1
EP 111: Combining human and machine intelligence in protein engineering with Dr. James Field, CEO of LabGenius 35:34

6M ago35:34

35:34

In this episode of The Genetics Podcast, we welcome Dr. James Field, founder and CEO of LabGenius. Join us as we delve into LabGenius' cutting-edge approach that utilises machine learning, artificial intelligence, and sophisticated robotics to advance antibody discovery and drug development. As a bonus, learn about James’ path from scientist to CEO…

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Healthy Holiday Eating 2023 18:16

6M ago18:16

18:16

This week on the Beth Linder-Moss Podcast, Beth discusses the challenges and opportunities of maintaining healthy diets in festive periods. This episode features a discussion about delicious, nutritious meals without sacrificing the essence of holiday celebrations or the progress made on their health-conscious journeys. To learn more about Beth, pl…

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EP 110: Educating the next generation of genomics talent, and the intersection of genetics and environment in cancer with Barbara Kraatz Fortini 35:41

6M ago35:41

35:41

On this episode of The Genetics Podcast we welcome Dr. Barbara Kraatz Fortini, Associate Professor of Genetics at Keck Graduate Institute (KGI). Tune in to learn about Barbara's research on non-coding variants in colorectal cancer and the interplay between genetics and the environment on lifetime cancer risk. As the Program Director for the MS in H…

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EP 109: From the Archives: Professor Sir Rory Collins on the Origins and Future of the UK Biobank 34:58

7M ago34:58

34:58

This week, we’re re-sharing one of our favorite episodes from the early days of The Genetics Podcast - one that many newer listeners may not have heard! Tune in as Professor Sir Rory Collins, Founder and Chief Executive of the UK Biobank, talks to us about the origins and evolution of this world-changing project that has catalysed a wave of new dis…

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Three Sports and the Gym 27:46

7M ago27:46

27:46

This week, best-selling author and social media tour de force, Beth Linder-Moss will show devotees of golf, martial arts, and/or dance how to revolutionize their training and outcomes. Whether you play or practice for yourself or competitively your results will improve as a result of what Beth teaches on this episode. Because as Beth will answer th…

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EP 108: Drug Development in Liver Disease: Breakthroughs, Challenges, and Insights with Dimitar Tonev 35:32

7M ago35:32

35:32

In this episode of The Genetics Podcast, we're joined by Dimitar Tonev, an experienced drug development consultant specialising in Hepatology and Virology. Tune in to discuss the recent reclassification of Non-alcoholic Steatohepatitis (NASH) to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and the complexities of identifying tr…

1
Reasons to Modify Workouts 21:05

7M ago21:05

21:05

On this edition of the Beth Linder-Moss podcast, Beth describes when and how to modify workouts. Modifications can be from injury, illness, or a need to avoid plateauing in a firtness regime. Surpringly it is possible to experience a vigorous workout even when changes are required. To learn more about Beth and order her book, 'Think Healthy Be Heal…

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EP 107: Integrating Genomics and Individualised Medicine into the Mayo Clinic Healthcare System with Dr. Konstantinos Lazaridis 28:43

8M ago28:43

28:43

In this episode of The Genetics Podcast, we welcome Dr. Konstantinos Lazaridis, the Executive Director of the Center for Individualized Medicine at the Mayo Clinic. Tune in to learn about the impacts of genomics and individualised medicine on rare liver diseases and advanced cancers . Discover how the Mayo Clinic actively uses genomic testing, prec…

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Ep 106: The Colliding World of Rare and Common Disease Genetics with Caroline Wright, Professor of Genomic Medicine at Exeter University 26:29

8M ago26:29

26:29

In this episode, Patrick welcomes Caroline Wright, a leading expert in genomic medicine and Professor of Genomic Medicine at Exeter University. Listen in as they delve into the world of rare diseases, discussing the challenges in diagnosis, uses of population cohorts and, the potential of newborn screening. Caroline shares her excitement about new …

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The Importance of Sleep 29:47

8M ago29:47

29:47

Americans are some of the most sleep deprived people in the world, and there are reasons for this. On this edition of the Beth Linder-Moss Podcast, Beth discusses the value and importance of sleep. How much sleep is enough and the benefits of getting a good night's sleep. Plus the downside of a sleep deficit, and what we all give up as a result. Yo…

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Nine Myths About Health and Fitness 21:31

8M ago21:31

21:31

On this episode, best-selling author and social media influencer Beth Linder-Moss will debunk the most common health and fitness myths. Our misunderstanding of these things can keep us off our path to overall fitness. Because it is poast time to demystify these misconceptions and provide tips and insights on achieving healthier, sustainable, fitnes…

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EP105: Warren Huff, CEO and Chairman of Reata Pharmaceuticals, shares perspectives on provocative biology and the development of treatments for rare diseases 47:29:00

8M ago47:29:00

47:29:00

In this episode, Patrick welcomes J. Warren Huff, CEO and Chairman of Reata Pharmaceuticals. Reata is known for innovating small-molecule therapies for severe and life-threatening diseases. Listen in as Warren walks us through their approach of partnering with Universities to find scientific discoveries that could become the next generation of ther…

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Stay Healthy and Fit as you Age 23:53

9M ago23:53

23:53

On this edition of the Beth Linder-Moss podcast, best selling author and social media influencer Beth Linder-Moss will help us all discover several keys to health and wellness for those who have the privilege of getting older, including what to eat and how to stay fit as we age. Beth gives examples of weight bearing/resistance exercises that do not…

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EP104: Assessing the clinical utility of Polygenic Risk Scores in cancer screening with Professor Clare Turnbull 43:49:00

9M ago43:49:00

43:49:00

Join Patrick Short and Professor Clare Turnbull, Professor in Translational Cancer Genetics at the Institute of Cancer Research, as they discuss polygenic risk scores and their application in healthcare. Delve into the complexities of predicting disease, the challenges of screening programs, and the potential impact of integrating genomics into hea…

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Excuses Excuses 26:51

9M ago26:51

26:51

Renowned fitness and wellness coach, Beth Linder-Moss, delves deep into the negative impact of excuses on our well-being during the latest episode of her widely acclaimed podcast. In this compelling installment, Linder-Moss sheds light on common excuses that hinder individuals from embracing a healthier lifestyle, urging her audience to take the ne…

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The Benefits of Protein 20:16

9M ago20:16

20:16

On this edition of the Beth Linder-Moss podcast, Beth describes the multiple benefits of protein in the diet, how much is enough, who needs it most, and who might be wary of too much. To learn more be sure to visit httpsbethlinder-moss.com.By Beth Linder-Moss

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Preventing Inflammation with Better Dietary Choices 12:05

9M ago12:05

12:05

For those who suffer from asthma, arthritis, and other autoimmune diseases can learn and benefit from this edition of the Beth Linder-Moss podcast. Beth describes the foods to avoid and those to eat more of along with the benefits of what these dietary changes will mean for individuals including how soon they will start to feel better.…

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EP103: Gene Writing with Tessera Therapeutics CEO, Dr. Mike Severino 43:33:00

9M ago43:33:00

43:33:00

In this episode, Patrick is joined by Dr. Mike Severino, CEO of Tessera Therapeutics and CEO-Partner of Flagship Pioneering. Join us as Mike walks us through Tessera’s approach to treating genetic diseases by rewriting bases, exons, or even whole genes with a novel approach called Gene Writing. 0:00 Intro1:00 What prompted you to join Flagship Pion…

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EP102: Dr. Marco Schmidt, founder and Chief Scientific Officer of BioTx.ai, on how to use artificial intelligence and machine learning in genomics research 37:36:00

10M ago37:36:00

37:36:00

0:00 Intro0:45 The founding of BioTx.ai4:35 How do algorithms for ‘causal inference’ work?6:30 Modeling gene interactions for genetic disorders8:35 How to predict gene interactions 10:30 What happens after identifying a potential gene variant or interaction?14:35 How can you use machine learning to determine causal relationships between gene varian…

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It Has To Be The Shoes 21:36

10M ago21:36

21:36

In a recent discussion on the importance of footwear, bestselling author and social media influencer, Beth Linder-Moss, shed light on the significance of selecting the right shoes for various activities. The conversation revolved around the relationship between footwear and different forms of exercise, specifically biking, running, hiking, and othe…

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EP101: Fostering international progress towards personalised medicine with Dr. Bettina Lundgren, CEO of the Danish National Genome Center 28:26:00

10M ago28:26:00

28:26:00

Join Patrick in welcoming Dr. Bettina Lundgren, CEO of the Danish National Genome Center. Bettina is spearheading the development of personalised medicine in Denmark with a focus on integrating genome sequencing directly into the healthcare system. She is dedicated to fostering international collaboration in research and healthcare delivery. Tune i…

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Should You Hire a Health and Wellness Coach? 16:02

11M ago16:02

16:02

On this edition of the Beth Linder-Moss Podcast, Beth answers the question, should you hire a personal health and wellness coach? The Beth Linder-Moss podcast features bestselling author and social media influencer, Beth Linder-Moss. The Beth Linder-Moss Podcast can be heard on Apple, Spotify, LibSyn, SoundCloud, Deezer, Audacy, Metaphor, TuneIn, a…

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EP100: Decoding DNA and engineering biology: perspectives on the future of genomics with Dr. Matthew Hurles, Director of the Wellcome Sanger Institute. 43:32:00

11M ago43:32:00

43:32:00

In this milestone episode, we welcome Dr Matthew Hurles, geneticist and pioneer in the field of human genomics. Dr Hurles has dedicated his career to unravelling the secrets hidden within our DNA, as well as harnessing cutting-edge research to revolutionise our understanding of genetic disorders, human evolution, and the potential for personalised …

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Beth Linder-Moss Easy New Habits for Better Health.MP3 54:44

11M ago54:44

54:44

How can anyone find time to work out, do so consistently, and effectively? Bestselling fitness author and social media influencer Beth Linder-Moss knows the best ways to form fitness habits, a little at a time with proper motivation, and a view to a desired future. She described some ways to incorporate heathier habits into the day on her podcast. …

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Ready for Summer Beth Linder Moss 15:44

11M ago15:44

15:44

With summer here in some parts of the country or just around the corner in others, there’s no better time to start working on your confidence and body goals. If you’re feeling a little overwhelmed and unsure, don’t worry – Beth Linder-Moss has you covered on her weekly podcast. To see more from Beth go to https://bethlinder-moss.com.…

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Harold Nicoll Podcasts

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