141 | Longevity and Healthspan (Part 3): Molecular Mechanisms of Aging and Loss of Resilience - Sirtuins and Telomeres

Inflammation Nation: Science Informed Wellness

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What if the secret to longevity lies not only in our genes but in our lifestyle choices and our resilience? Welcome back to another engaging episode of Inflammation Nation. This time, we take a leap into the subject of aging and resilience, zooming in on how this gradual process impacts our bodies differently and at varying rates. Listen closely as we unmask the markers of resilience in your body systems and unravel the importance of maintaining balance and control amidst stress.
We then venture into the fascinating realm of cellular aging, shedding light on the structural and functional abnormalities that occur in our organs due to accumulated damage. Have you ever wondered why more people are living past a century but aren't necessarily healthier in their bonus years? We dissect this paradox, highlighting differences in longevity between men and women. Our exploration goes deeper to discuss fertility, childbearing, and caregiving and their intriguing impacts on brain health, hormonal balance, and immune system competence.
Lastly, in the quest to answer the question: "How can we retain resilience as we age and improve our health span?" we dig into the world of genetics, focusing on the APOE gene and unique gene mutations. We also illuminate our paths with the molecular mechanisms of longevity, including the role of telomeres, DNA repair, and the heroes of the story, the sirtuins, in ensuring we age well. Get ready for an intense, enlightening session as we dissect longevity, telomeres, and cellular aging. Let's unravel the secrets of aging well, together.

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Chapters

1. 141 | Longevity and Healthspan (Part 3): Molecular Mechanisms of Aging and Loss of Resilience - Sirtuins and Telomeres (00:00:00)

2. Unlocking Resilience (00:00:01)

3. Understanding Aging and Longevity Trends (00:03:58)

4. Factors Influencing Longevity (00:08:25)

5. Longevity, Telomeres, and Cellular Aging (00:15:06)

6. Impact of Natural Compounds on Longevity (00:24:59)