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Thalamus Grand Rounds is a podcast created by and for current and former residents, program coordinators and directors to spotlight and empower GME leaders to innovate the residency and fellowship recruitment processes. You’ll hear insightful discussions about all things GME including virtual interview best practices, managing expectations of applicants and faculty, promoting DEI initiatives and holistic review, data and analytics to drive recruitment and much more.
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Playing With Marbles

Vocal Fry Studios, Brain Canada

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Is your relationship with your brain a little... complicated? Playing with Marbles is about the complicated interplay between the brain and the rest of the body. We're investigating how the brain actually works, and how that affects who we are. We have healthy brains, dead brains, brains in jars, and brain power of incredible researchers, doctors, and everyday people. Come and find out what's going on with your marble... for science!
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Neuroscience Perspectives

Del Monte Institute for Neuroscience at the University of Rochester

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Immerse yourself in the fascinating world of neuroscience with our expert guests as they explore the mysteries of the brain and the latest breakthroughs in research with our host, John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester. Each episode features in-depth conversations with leading scientists, who unravel complex topics and tackle intriguing questions like: How does the brain shape our behavior? What role do genetics play in our health? ...
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PsyDactic

T. Ryan O'Leary

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A resource for psychiatrists and other medical or behavioral health professionals interested in exploring the neuroscientific basis of psychiatric disorders, psychopharmacology, neuromodulation, and other psychiatric interventions, as well as discussions of pseudoscience, Bayesian reasoning, ethics, the history of psychiatry, and human psychology in general. This podcast is not medical advice. It strives to be science communication. Dr. O'Leary is a skeptical thinker who often questions what ...
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Wind Ministries equips people to experience God by introducing them to the heart of Jesus, encouraging them to learn and grow in the prophetic, and guiding them in the pursuit of spiritual formation so that they can understand their personal experiences are part of a much larger story. On the Wind Ministries Podcast, you will find teaching resources from Joshua and Erin Hoffert (as well as others) ranging from practical conversations about the spiritual life to a deep dive into the lives of ...
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In this special episode of Neuroscience Perspectives, host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, sits down with S. Murray Sherman, PhD, Maurice Goldblatt Professor of Neurobiology at the University of Chicago, in Chicago at the annual Society for Neuroscience (SfN) conference. Sherman i…
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In this episode of Neuroscience Perspectives, we dive into the microscopic world of C. elegans—tiny roundworms that are revolutionizing our understanding of genetics and behavior. Join host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester as he chats with Doug Portman, PhD, the Donald M. Foster Pro…
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José Alain Sahel, MD, is a distinguished professor, eye and ear foundation professor, and chair of the Department of Ophthalmology at the University of Pittsburgh School of Medicine. He is also the director of the UPMC Vision Institute. Dr. Sahel is a leading expert in retinal diseases and vision restoration research and is a pioneer in optogenetic…
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Is there a defining moment that set you on your current path? In this episode of Neuroscience Perspectives, we’re revisiting origin stories – what launched leading neuroscientists into a lifetime of learning and interest in the brain. Host: John Foxe, PhD, director of the Del Monte Institute for Neuroscience Guests (in order of appearance): Nathan …
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Send us a text Dr. O'Leary discusses the term Transference, and if you listen until the end, he relates it to some computational neuroscience. Transference is a historically loaded term. Transference is supposed to be an unconscious process, so it can not really be observed, only inferred, so this means that both the definition of transference and …
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Send us a text -- More recently I have faced the diagnostic conundrum of catatonia in autism, and that is what I want to explore in more excruciating detail today. There is surprisingly little literature on the subject, and that is concerning because being able to identify and treat catatonia can be life-saving, not to mention life-altering for pat…
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How often do you think about science fits into your lifeand how you fit into the field? For our 20th episode we are looking back at some of the advice that’s been shared by our guests on Neuroscience Perspectives. Host: John Foxe, PhD, director of the Del MonteInstitute for Neuroscience Guests (in order of appearance): Katalin Gothard, PhD, profess…
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Send us a text -- Dr. O’Leary interviews forensic psychiatrist and author Dr. Michael Schirripa about his career as a forensic psychiatrist, the release of his first thriller, Mindhunt, and his podcast Mindhunting. Dr. Shirripa explores how his love of literature influenced his decision to pursue forensic psychiatry and ultimately resulted in his c…
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Send us a text - - In the world of psychotropic medication, the question is not just whether it works or not, but whether it works better than a placebo and whether the effect size is clinically significant and the benefits outweigh the risks. In the case of MDMA (aka molly or ecstasy), the effect size for improving post-traumatic stress disorder s…
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Send us a text The Narrative Fallacy describes our tendency to find meaning, connections, and causal relationships where they do not necessarily exist. In this episode, Dr. O'Leary had the pleasure of interviewing Dr. Alexey Tolchinsky. He recently published a paper called “Narrative fallacy and other limitations of psychodynamic case formulation.”…
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Send us a text Dr. O'Leary discusses a variety of concerns that all clinicians should have in mind when using psychometrics. In the end, he hopes you come away with some level of agreement with the statement: “Our primary concern should not be with the quantity of data, but with the quality of the data.” Statistics are conceptual machines that will…
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Kia Nobre, PhD, is the director of the Center for Neurocognition and Behavior at the Wu Tsai Institute at Yale University. Her discoveries have revolutionized our scientific understanding of the human mind and #brain. She tells John Foxe, PhD, director of the Del Monte Institute for Neuroscience, about the great gift she acquired as a child that le…
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We've talked about the thalamus as the smoke detector of the brain, now its time to move on to layer 2: the amygdala. Once we have detected that external stimulus is happening, how we respond is largely influenced by how our amygdala has been formed since childhood. Tune in as Josh and Ken talk about the role of the amygdala and how we learn fight,…
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Send us a text In this episode, Dr. O'Leary discusses a word that he has struggled to understand since medical school. The word is aphasia. The root “phasia” comes from the Greek phanai which means “to speak.” When aphasia is used medically, it refers to an inability to speak, although not always. More generally it is often used to mean a failure t…
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What does the Thalamus have to do with spiritual and emotional health. Is there something about how the brain develops that gives us insight into the way we go about maturing and growing? And what happens is we miss those things? Join Joshua and Ken Hoffert as they talk about the layers of the brain, spiritual and emotional health, and that weird l…
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Did you know the brain goes through 4 stages of development? And that those stages correspond to our maturation and age? And what does the Lord's Prayer and the story of Cain and Abel have to do with this? Pain and trauma have a way of impacting each of these stages in unique ways. Join Joshua and Ken Hoffert as they dive in and break down how we a…
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Takao Hensch, PhD, is a professor of Neurology at Harvard Medical School at Boston Children’s Hospital and a professor of Molecular and Cellular Biology at Harvard’s Center for Brain Science. He leads the National Institute of Mental Health Silvio Conte Center on Mental Health Research at Harvard and the International Research Center for Neurointel…
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What are we to do when we encounter anger, fear, sadness, shame, disgust, and hopelessness.? These are our most uncomfortable moments. In difficult moment, we either ignore, succumb to, or stuff these are the emotions. But what if there is a better way? And what if, when we looked at Jesus, we noticed that he did not avoid any emotional expression?…
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Support If you’re struggling with your mental health, you’re not alone. If you are in immediate danger of harming yourself or others, call 9-1-1, or head to your nearest emergency room. You can also call or text 9-8-8 to reach the Suicide Crisis Helpline. Support is available 24 hours a day, 7 days a week. Young people can chat anytime with Kids He…
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Send us a text I did not until recently even consider the cerebellum when thinking about psychiatric conditions, but the more I read, the more I wonder why the cerebellum is not considered a potential important player in nearly every psychiatric disorder. Although it can be said that all brain regions primarily function to make predictions, the cer…
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Why does maturity (both spiritual and emotional) seem so elusive? And why does it seem as though we either don't have it, only others possess it, or we only seem to stumble into it? Join Joshua and Ken Hoffert as they dive into how we can go about expecting spiritual and emotional health. For more about Wind Ministries, visit: https://www.windminis…
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Join us for a new series on the Wind Ministries podcast: The Spiritual Maturity Series! Josh and Ken dive deep into the topics of spiritual maturity, brain science, attachment theory, and stages of development. In this inaugural episode, Josh and Ken talk about what a spiritually healthy and vibrant person looks like according to the words of Jesus…
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Send us a text The thalami are bilaterally symmetrical structures in the subcortical part of the brain that are cradled by the basal ganglia. They are major hubs of pretty much everything your brain does and all of the sensory information coming into the brain with the exception of smell. More primitive models of the brain visualized it as a bunch …
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How are injury and illness monitored in the brain? Once thought of as the glue of the brain, glia cells have been proven to play a key role in brain health with astrocytes acting as important messengers. These star-like cells are at the center of the research of Nathan A. Smith, PhD, associate dean for Equity & Inclusion for Research and Research E…
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Send us a text In this episode, I discuss a medication that patients who saw a psychiatrist or their primary care provider between about 1997 and 2015 were very likely to find themselves prescribed. More recently, it has been taken down a notch or two on prescribers lists of preferred meds. This medication is quetiapine, marketed as Seroquel by Ast…
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Send us a text This episode continues an intermittent series called “In a Word.” Past episodes have explored words like Akathisia, Dissociation, Perseveration, and even the difference between Impulsive and Compulsive. This episode explores Confabulation, including some of the brain circuits involved, and what might differentiate confabulation from …
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The term “dissociation” is a hot topic amongst those who study the brain. An example of dissociation that most of us can relate to is when you’re reading or scrolling through social media and you realize that your mind is elsewhere, that you haven’t actually absorbed the information in front of you. Some researchers have termed these momentary and …
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What changes happen at the cellular level in the cerebral cortex between concentration and daydreaming? Jessica Cardin, PhD, associate professor and vice chair of the Neuroscience Department at Yale School of Medicine, joins John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, on NeURoscience Perspect…
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Diagnosis of personality disorders in youth is relatively new. Before the release of the Diagnostic and Statistical Manual, version 5 (DSM-V), nobody under the age of 18 could receive a diagnosis of a personality disorder, mainly due to the transitional nature of personality in youth, and the degree of stigmatization attached to such a diagnosis. R…
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Send us a text In 2012 the Supreme Court heard two related cases involving adolescents convicted of murder and sentenced to life in prison without parole because of mandatory minimum sentencing guidelines in their states. One of the boys, Evan Miller along with an accomplice, had beat a man unconscious with a baseball bat after a fight that ensued …
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The definition of Attention Deficit Hyperactivity Disorder (ADHD) has gone through many changes over the years. Interestingly, the criteria used to diagnose ADHD has actually become broader, encompassing a wider range of ages and a variety of different clinical presentations and symptoms. One thing that’s stayed the same since the release of the DS…
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Anxiety is one of the body’s natural responses to stress. When a person is met with an important event or perceived danger, anxiety can help them to react to that stressor. But when symptoms of anxiety are ongoing or severe, it’s a sign of an anxiety disorder. There are several types of anxiety disorders, with each subtype categorized by how anxiet…
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Send us a text I am lucky today to be able to bring you an interview with Dr. Zac Brooks who is passionate about serious mental illness (SMI). “What is serious mental illness?” you might ask. That is one of the things we are going to discuss, and you may be surprised when Dr. Brooks explains how it was first formally defined. We also discuss the nu…
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How does the brain perceive touch? How does it process pain?Could what we know about pain better inform treatments for addiction? Fan Wang, PhD, professor in the Brain and Cognitive Sciences department at the McGovern Institute for Brain Research at MIT, joins John Foxe, PhD, director of the DelMonte Institute for Neuroscience at the University of …
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Being sad or feeling hopeless is a normal part of human existence appearing and disappearing and reappearing with the ebbs and flows of life. But when symptoms of a depressive episode last for more than two weeks, and begin to get in the way of one’s day-to-day life, that’s when a person meets the criteria for Major Depressive Disorder, or MDD, whi…
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Strap in for another exciting season of Playing With Marbles, brought to you by Brain Canada. In past seasons, we learned about all of the cool brain science research coming out of labs in Canada, from mini-brain organoids in petri dishes to women’s health beyond the bikini. We’ve taken a look at the brain at a microscopic level and learned how eac…
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Send us a text PsyDactic welcomes Dr. Jon Lindefjeld for a discussion of the history of HIV and AIDS. In particular, we discuss the development of effective antiretroviral therapies, including pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), highlighting the CDC guidelines for use and monitoring, need to treat psychiatric com-mo…
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Send us a text Dr. O'Leary discusses some of the history of the borderline personality, how different perspectives have attempted to explain its origin, how to treat it and how not to treat it. He starts in 1947 with some colorful descriptions of patients living with borderline personality disorder that would never get published today, and highligh…
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Send us a text Our current diagnostic criteria for personality disorders have failed to demonstrate validity or reliability. The DSM 5 encouraged psychiatrists to start considering a broad range of personality features adapted from the Five Factor Model. These are combined with global functioning measures to build a personality inventory for any pa…
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Send us a text Humans have a history of tattooing that stretches millennia into prehistory. The western ban on tattoos by the early church resulted in a systematic effort to paint tattooed individuals as pagan, primitive, vulgar, criminal, and mentally ill. Psychiatrists have historically contributed to this characterization but are in a position t…
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Send us a text The brain understands the world by building models that predict the future. One of the ways that it does this is by utilizing attractor networks. These small world networks are constantly trying to determine what is a true signal from the constant noise in the neural net. Dr. O'Leary explores how attractor networks have been hypothes…
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