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PREVIEW Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health
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Manage episode 286971319 series 2891560
Content provided by Rhonda Patrick, Ph.D. and Rhonda Patrick. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rhonda Patrick, Ph.D. and Rhonda Patrick or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health. In this episode, we discuss:
…
continue reading
- (00:00) Introduction
- (03:23) The role of both mTOR and the IGF-1 pathway in cellular growth and their regulation by amino acids (Peter Attia discussion)
- (11:50) Living longer as a function of preventing insidious damage to our cells and tissues
- (14:53) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans (Valter Longo discussion)
- (17:10) Effects of IGF-1 on human lifespan
- (23:01) Refeeding that follows fasting mimicking creates an environment that may be just right for the regeneration of healthy cells
- (25:55) The growth-longevity trade-off (Rhonda Patrick & Mike Maser discussion)
25 episodes
MP3•Episode home
Manage episode 286971319 series 2891560
Content provided by Rhonda Patrick, Ph.D. and Rhonda Patrick. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rhonda Patrick, Ph.D. and Rhonda Patrick or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health. In this episode, we discuss:
…
continue reading
- (00:00) Introduction
- (03:23) The role of both mTOR and the IGF-1 pathway in cellular growth and their regulation by amino acids (Peter Attia discussion)
- (11:50) Living longer as a function of preventing insidious damage to our cells and tissues
- (14:53) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans (Valter Longo discussion)
- (17:10) Effects of IGF-1 on human lifespan
- (23:01) Refeeding that follows fasting mimicking creates an environment that may be just right for the regeneration of healthy cells
- (25:55) The growth-longevity trade-off (Rhonda Patrick & Mike Maser discussion)
25 episodes
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